TY - JOUR
T1 - In vitro anti-plasmodial activity of three herbal remedies for malaria in Ghana
T2 - Adenia cissampeloides (Planch.) Harms., Termina liaivorensis A. Chev, and Elaeis guineensis Jacq
AU - Annan, Kofi
AU - Sarpong, K.
AU - Asare, C.
AU - Dickson, R.
AU - Amponsah, Kl
AU - Gyan, B.
AU - Ofori, M.
AU - Gbedema, S. Y.
PY - 2012/10
Y1 - 2012/10
N2 - Background: Herbal remedies of Adenia cissampeloides, Terminalia ivorensis, and Elaeis guineensis among others have been used in Ghana for the treatment of various ailments including malaria. However, most of these remedies have not been scientifically investigated. Objective: This study, therefore, seeks to investigate the anti-plasmodial activity of these plants. Materials and Methods: The ethanolic extracts of A. cissampeloides stem, T. ivorensis stem bark, and E. guineensis leaves were tested for in vitro anti-plasmodial activity against chloroquine-resistant strains of Plasmodium falciparum. Thin blood films were used to assess the level of parasitemia and growth inhibition of the extracts. Results: The IC50 of A. cissampeloides, T. ivorensis, and E. guineensis were 8.521, 6.949, and 1.195 g/ml, respectively, compared to artesunate with IC50 of 0.031 g/ml. Conclusion: The result of this study appears to confirm the folkloric anti-malarial use these plants.
AB - Background: Herbal remedies of Adenia cissampeloides, Terminalia ivorensis, and Elaeis guineensis among others have been used in Ghana for the treatment of various ailments including malaria. However, most of these remedies have not been scientifically investigated. Objective: This study, therefore, seeks to investigate the anti-plasmodial activity of these plants. Materials and Methods: The ethanolic extracts of A. cissampeloides stem, T. ivorensis stem bark, and E. guineensis leaves were tested for in vitro anti-plasmodial activity against chloroquine-resistant strains of Plasmodium falciparum. Thin blood films were used to assess the level of parasitemia and growth inhibition of the extracts. Results: The IC50 of A. cissampeloides, T. ivorensis, and E. guineensis were 8.521, 6.949, and 1.195 g/ml, respectively, compared to artesunate with IC50 of 0.031 g/ml. Conclusion: The result of this study appears to confirm the folkloric anti-malarial use these plants.
KW - Adenia cissampeloides
KW - Anti-plasmodial
KW - Elaeis guineensis
KW - Herbal remedies
KW - Terminalia ivorensis
UR - http://www.scopus.com/inward/record.url?scp=84870186377&partnerID=8YFLogxK
U2 - 10.4103/0974-8490.102270
DO - 10.4103/0974-8490.102270
M3 - Article
AN - SCOPUS:84870186377
SN - 0974-8490
VL - 4
SP - 225
EP - 229
JO - Pharmacognosy Research
JF - Pharmacognosy Research
IS - 4
ER -
