TY - JOUR
T1 - Impact of blood perilipin A levels on obesity and metabolic health
AU - Ofori, Emmanuel K.
AU - Letsu, Bright Selorm
AU - Amponsah, Seth K.
AU - Ahenkorah, John
AU - Crabbe, Sandra
AU - Kwao-Zigah, Genevieve
AU - Oppong, Sylvester Y.
AU - Diaba-Nuhoho, Patrick
AU - Amanquah, Seth D.
N1 - Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Objective: Perilipin A is a common protein that coats lipid surfaces preventing them from being exposed to oxidative damage. Researchers have found little consistency in the relationship between perilipin A levels in the blood and body fat. This study was a cross-sectional observational that looked at circulating perilipin A levels and how they relate to metabolic health. Results: The participants in this study were 86 individuals with a mean age of 45.5 ± 1.2 years. Multiple clinical and metabolic indicators (age, weight, BMI, total body fat mass, triglyceride, and HOMA-IR) were shown to be inversely associated with perilipin A levels (rho = − 0.32, − 0.37, − 0.40, − 0.45, − 0.33 and − 0.29; p < 0.05 respectively). Obese persons were almost six times more likely than non-obese individuals to have lower perilipin A levels (odds ratio = 6.22, CI = 2.35–11.50, p < 0.001). Our findings underscore the important role of perilipin A proteins in metabolic health.
AB - Objective: Perilipin A is a common protein that coats lipid surfaces preventing them from being exposed to oxidative damage. Researchers have found little consistency in the relationship between perilipin A levels in the blood and body fat. This study was a cross-sectional observational that looked at circulating perilipin A levels and how they relate to metabolic health. Results: The participants in this study were 86 individuals with a mean age of 45.5 ± 1.2 years. Multiple clinical and metabolic indicators (age, weight, BMI, total body fat mass, triglyceride, and HOMA-IR) were shown to be inversely associated with perilipin A levels (rho = − 0.32, − 0.37, − 0.40, − 0.45, − 0.33 and − 0.29; p < 0.05 respectively). Obese persons were almost six times more likely than non-obese individuals to have lower perilipin A levels (odds ratio = 6.22, CI = 2.35–11.50, p < 0.001). Our findings underscore the important role of perilipin A proteins in metabolic health.
KW - Insulin resistance
KW - Lipids
KW - Obesity
KW - Perilipin A
UR - http://www.scopus.com/inward/record.url?scp=85143785039&partnerID=8YFLogxK
U2 - 10.1186/s13104-022-06261-3
DO - 10.1186/s13104-022-06261-3
M3 - Article
C2 - 36503541
AN - SCOPUS:85143785039
SN - 1756-0500
VL - 15
JO - BMC Research Notes
JF - BMC Research Notes
IS - 1
M1 - 367
ER -