Impact of blood perilipin A levels on obesity and metabolic health

Emmanuel K. Ofori, Bright Selorm Letsu, Seth K. Amponsah, John Ahenkorah, Sandra Crabbe, Genevieve Kwao-Zigah, Sylvester Y. Oppong, Patrick Diaba-Nuhoho, Seth D. Amanquah

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Objective: Perilipin A is a common protein that coats lipid surfaces preventing them from being exposed to oxidative damage. Researchers have found little consistency in the relationship between perilipin A levels in the blood and body fat. This study was a cross-sectional observational that looked at circulating perilipin A levels and how they relate to metabolic health. Results: The participants in this study were 86 individuals with a mean age of 45.5 ± 1.2 years. Multiple clinical and metabolic indicators (age, weight, BMI, total body fat mass, triglyceride, and HOMA-IR) were shown to be inversely associated with perilipin A levels (rho = − 0.32, − 0.37, − 0.40, − 0.45, − 0.33 and − 0.29; p < 0.05 respectively). Obese persons were almost six times more likely than non-obese individuals to have lower perilipin A levels (odds ratio = 6.22, CI = 2.35–11.50, p < 0.001). Our findings underscore the important role of perilipin A proteins in metabolic health.

Original languageEnglish
Article number367
JournalBMC Research Notes
Volume15
Issue number1
DOIs
Publication statusPublished - Dec 2022

Keywords

  • Insulin resistance
  • Lipids
  • Obesity
  • Perilipin A

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