Immunological and Haematological Relevance of Helminths and Mycobacterium tuberculosis Complex Coinfection among Newly Diagnosed Pulmonary Tuberculosis Patients from Bobo-Dioulasso, Burkina Faso

Diakourga Arthur Djibougou, Gloria Ivy Mensah, Achille Kaboré, Inoussa Toé, Leon Tinnoga Sawadogo, Palpouguini Felix Lompo, Amariane M.M. Kone, Hervé Hien, Clement Ziemlé Meda, Adjima Combary, Bassirou Bonfoh, Kennedy Kwasi Addo, Adrien Marie Gaston Belem, Roch Konbobr Dabiré, Jonathan Hoffmann, Matthieu Perreau, Potiandi Serge Diagbouga

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of helminthiasis on host immunity is a neglected area of research, particularly in tuberculosis (TB) infection. This study aimed to evaluate the effect of helminthiasis on immunological and haematological parameters in newly diagnosed TB patients in Bobo-Dioulasso. After all biological analyses, we formed three subpopulations: group 1 (n = 82), as control, were participants without helminthic or Mycobacterium tuberculosis complex infection (Mtb−/Helm−), group 2 (n = 73) were TB patients without helminthic infection (Mtb+/Helm−), and group 3 (n = 22) were TB patients with helminthic infection (Mtb+/Helm+). The proportion of helminth coinfection was 23.16% (22/95) in TB patients, and Schistosoma mansoni infection was found in 77.3% (17/22) cases of helminthiasis observed in this study. A low CD4 T cell count and a low CD4:CD8 ratio were significantly associated with concomitant infection with helminths and the Mtb complex (Mtb+/Helm+) compared to the other groups (p < 0.05). However, there was no statistically significant difference in the CD8 median among the three participating groups (p > 0.05). Lymphopenia, monocytosis, thrombocytosis, and hypochromic microcytic anaemia were the haematological defects observed in the Mtb+/Helm+ and Mtb+/Helm− patients. Exploring these types of immune–haematological biomarkers would be a valuable aid in diagnosing and a better follow-up and monitoring of the tuberculosis–helminthiasis coinfection.

Original languageEnglish
Article number1472
JournalBiomedicines
Volume12
Issue number7
DOIs
Publication statusPublished - Jul 2024
Externally publishedYes

Keywords

  • CD4 T cells
  • CD4:CD8 ratio
  • M. tuberculosis complex and helminth coinfection
  • immune–haematological parameters

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