TY - JOUR
T1 - Hydroxyapatite nano-pillars on TI-6Al-4V
T2 - Enhancements in cell spreading and proliferation during cell/surface integration
AU - Osafo, Sarah Akua
AU - Etinosa, Precious Osayamen
AU - Obayemi, John David
AU - Salifu, Ali Azeko
AU - Asumadu, Tabiri
AU - Klenam, Desmond
AU - Agyei-Tuffour, Benjamin
AU - Dodoo-Arhin, David
AU - Yaya, Abu
AU - Soboyejo, Winston Oluwole
N1 - Publisher Copyright:
© 2024 Wiley Periodicals LLC.
PY - 2024
Y1 - 2024
N2 - Despite the attractive combinations of cell/surface interactions, biocompatibility, and good mechanical properties of Ti-6Al-4V, there is still a need to enhance the early stages of cell/surface integration that are associated with the implantation of biomedical devices into the human body. This paper presents a novel, easy and reproducible method of nanoscale and nanostructured hydroxyapatite (HA) coatings on Ti-6Al-4V. The resulting nanoscale coatings/nanostructures are characterized using a combination of Raman spectroscopy, scanning electron microscopy equipped with energy dispersive x-ray spectroscopy. The nanostructured/nanoscale coatings are shown to enhance the early stages of cell spreading and integration of bone cells (hFOB cells) on Ti-6Al-4V surfaces. The improvements include the acceleration of extra-cellular matrix, cell spreading and proliferation by nanoscale HA structures on the coated surfaces. The implications of the results are discussed for the development of HA nanostructures for the improved osseointegration of Ti-6Al-4V in orthopedic and dental applications.
AB - Despite the attractive combinations of cell/surface interactions, biocompatibility, and good mechanical properties of Ti-6Al-4V, there is still a need to enhance the early stages of cell/surface integration that are associated with the implantation of biomedical devices into the human body. This paper presents a novel, easy and reproducible method of nanoscale and nanostructured hydroxyapatite (HA) coatings on Ti-6Al-4V. The resulting nanoscale coatings/nanostructures are characterized using a combination of Raman spectroscopy, scanning electron microscopy equipped with energy dispersive x-ray spectroscopy. The nanostructured/nanoscale coatings are shown to enhance the early stages of cell spreading and integration of bone cells (hFOB cells) on Ti-6Al-4V surfaces. The improvements include the acceleration of extra-cellular matrix, cell spreading and proliferation by nanoscale HA structures on the coated surfaces. The implications of the results are discussed for the development of HA nanostructures for the improved osseointegration of Ti-6Al-4V in orthopedic and dental applications.
KW - accelerated extracellular matrix and cell spreading
KW - hydroxyapatite nanostructures
KW - improved cell spreading and proliferation
KW - orthopedic/dental applications
KW - pack cementation
UR - http://www.scopus.com/inward/record.url?scp=85190950987&partnerID=8YFLogxK
U2 - 10.1002/jbm.a.37726
DO - 10.1002/jbm.a.37726
M3 - Article
C2 - 38630051
AN - SCOPUS:85190950987
SN - 1549-3296
JO - Journal of Biomedical Materials Research - Part A
JF - Journal of Biomedical Materials Research - Part A
ER -