HIV drug resistance in children and adolescents on NNRTI-based antiretroviral therapy and subsequent virologic response to dolutegravir-based regimens in Ghana

Adwoa K.A. Afrane; Vlad Novitsky; Joel Hague; Kwamena Sagoe; Yakubu Alhassan; Joycelyn Assimeng Dame; Charles Martyn-Dickens; Margaret Lartey; Bamenla Goka; Kwasi Torpey; Rami Kantor; Awewura Kwara

doi:10.1186/s12981-025-00762-4

HIV drug resistance in children and adolescents on NNRTI-based antiretroviral therapy and subsequent virologic response to dolutegravir-based regimens in Ghana

Adwoa K.A. Afrane, Vlad Novitsky, Joel Hague, Kwamena Sagoe, Yakubu Alhassan, Joycelyn Assimeng Dame, Charles Martyn-Dickens, Margaret Lartey, Bamenla Goka, Kwasi Torpey, Rami Kantor, Awewura Kwara

Research output: Contribution to journal › Article › peer-review

Abstract

HIV drug resistance (HIVDR) was retrospectively characterized among 20 children and adolescents with HIV with virologic failure on non-nucleoside reverse transcriptase inhibitor (NNRTI)-based therapy, and virologic response in those switched to dolutegravir (DTG)-based therapy described. All participants had at least one NNRTI resistance mutation, most commonly K103N (N = 12) and 15 (75%) had nucleoside reverse transcriptase inhibitor (NRTI) resistance mutations, most commonly M184I/V (N = 15). Five (45%) of 11 participants who were switched to DTG-based regimens for a median of 50 months had HIV suppression. Further studies to understand the role of pre-existing HIVDR in the failure of DTG-based regimens are needed.

Original language	English
Article number	74
Journal	AIDS Research and Therapy
Volume	22
Issue number	1
DOIs	https://doi.org/10.1186/s12981-025-00762-4
Publication status	Published - Dec 2025

Keywords

Antiretroviral therapy
Children and adolescents
Dolutegravir
Ghana
HIV drug resistance
NNRTIs

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/s12981-025-00762-4

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Afrane, A. K. A., Novitsky, V., Hague, J., Sagoe, K., Alhassan, Y., Dame, J. A., Martyn-Dickens, C., Lartey, M., Goka, B., Torpey, K., Kantor, R., & Kwara, A. (2025). HIV drug resistance in children and adolescents on NNRTI-based antiretroviral therapy and subsequent virologic response to dolutegravir-based regimens in Ghana. AIDS Research and Therapy, 22(1), Article 74. https://doi.org/10.1186/s12981-025-00762-4

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title = "HIV drug resistance in children and adolescents on NNRTI-based antiretroviral therapy and subsequent virologic response to dolutegravir-based regimens in Ghana",

abstract = "HIV drug resistance (HIVDR) was retrospectively characterized among 20 children and adolescents with HIV with virologic failure on non-nucleoside reverse transcriptase inhibitor (NNRTI)-based therapy, and virologic response in those switched to dolutegravir (DTG)-based therapy described. All participants had at least one NNRTI resistance mutation, most commonly K103N (N = 12) and 15 (75\%) had nucleoside reverse transcriptase inhibitor (NRTI) resistance mutations, most commonly M184I/V (N = 15). Five (45\%) of 11 participants who were switched to DTG-based regimens for a median of 50 months had HIV suppression. Further studies to understand the role of pre-existing HIVDR in the failure of DTG-based regimens are needed.",

keywords = "Antiretroviral therapy, Children and adolescents, Dolutegravir, Ghana, HIV drug resistance, NNRTIs",

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doi = "10.1186/s12981-025-00762-4",

language = "English",

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Afrane, AKA, Novitsky, V, Hague, J, Sagoe, K, Alhassan, Y, Dame, JA, Martyn-Dickens, C, Lartey, M, Goka, B, Torpey, K, Kantor, R & Kwara, A 2025, 'HIV drug resistance in children and adolescents on NNRTI-based antiretroviral therapy and subsequent virologic response to dolutegravir-based regimens in Ghana', AIDS Research and Therapy, vol. 22, no. 1, 74. https://doi.org/10.1186/s12981-025-00762-4

TY - JOUR

T1 - HIV drug resistance in children and adolescents on NNRTI-based antiretroviral therapy and subsequent virologic response to dolutegravir-based regimens in Ghana

AU - Afrane, Adwoa K.A.

AU - Novitsky, Vlad

AU - Hague, Joel

AU - Sagoe, Kwamena

AU - Alhassan, Yakubu

AU - Dame, Joycelyn Assimeng

AU - Martyn-Dickens, Charles

AU - Lartey, Margaret

AU - Goka, Bamenla

AU - Torpey, Kwasi

AU - Kantor, Rami

AU - Kwara, Awewura

N1 - Publisher Copyright: © The Author(s) 2025.

PY - 2025/12

Y1 - 2025/12

N2 - HIV drug resistance (HIVDR) was retrospectively characterized among 20 children and adolescents with HIV with virologic failure on non-nucleoside reverse transcriptase inhibitor (NNRTI)-based therapy, and virologic response in those switched to dolutegravir (DTG)-based therapy described. All participants had at least one NNRTI resistance mutation, most commonly K103N (N = 12) and 15 (75%) had nucleoside reverse transcriptase inhibitor (NRTI) resistance mutations, most commonly M184I/V (N = 15). Five (45%) of 11 participants who were switched to DTG-based regimens for a median of 50 months had HIV suppression. Further studies to understand the role of pre-existing HIVDR in the failure of DTG-based regimens are needed.

AB - HIV drug resistance (HIVDR) was retrospectively characterized among 20 children and adolescents with HIV with virologic failure on non-nucleoside reverse transcriptase inhibitor (NNRTI)-based therapy, and virologic response in those switched to dolutegravir (DTG)-based therapy described. All participants had at least one NNRTI resistance mutation, most commonly K103N (N = 12) and 15 (75%) had nucleoside reverse transcriptase inhibitor (NRTI) resistance mutations, most commonly M184I/V (N = 15). Five (45%) of 11 participants who were switched to DTG-based regimens for a median of 50 months had HIV suppression. Further studies to understand the role of pre-existing HIVDR in the failure of DTG-based regimens are needed.

KW - Antiretroviral therapy

KW - Children and adolescents

KW - Dolutegravir

KW - Ghana

KW - HIV drug resistance

KW - NNRTIs

UR - https://www.scopus.com/pages/publications/105011715135

U2 - 10.1186/s12981-025-00762-4

DO - 10.1186/s12981-025-00762-4

M3 - Article

AN - SCOPUS:105011715135

SN - 1742-6405

VL - 22

JO - AIDS Research and Therapy

JF - AIDS Research and Therapy

IS - 1

M1 - 74

ER -

HIV drug resistance in children and adolescents on NNRTI-based antiretroviral therapy and subsequent virologic response to dolutegravir-based regimens in Ghana

Abstract

Keywords

UN SDGs

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