TY - JOUR
T1 - Global Respiratory Syncytial Virus-Related Infant Community Deaths
AU - CHAMPS Network the RSV GOLD Study Groupa
AU - Mazur, Natalie I.
AU - Löwensteyn, Yvette N.
AU - Willemsen, Joukje E.
AU - Gill, Christopher J.
AU - Forman, Leah
AU - Mwananyanda, Lawrence M.
AU - Blau, Dianna M.
AU - Breiman, Robert F.
AU - Madhi, Shabir A.
AU - Mahtab, Sana
AU - Gurley, Emily S.
AU - El Arifeen, Shams
AU - Assefa, Nega
AU - Scott, J. Anthony G.
AU - Onyango, Dickens
AU - Tippet Barr, Beth A.
AU - Kotloff, Karen L.
AU - Sow, Samba O.
AU - Mandomando, Inacio
AU - Ogbuanu, Ikechukwu
AU - Jambai, Amara
AU - Bassat, Quique
AU - Thamthitiwat, Somsak
AU - Gentile, Angela
AU - Lucion, Maria Florencia
AU - Pires, Márcia Rosane
AU - De-Paris, Fernanda
AU - Gordon, Aubree
AU - Sánchez, José Félix
AU - Lucero, Marilla G.
AU - Lupisan, Socorro P.
AU - Gessner, Bradford D.
AU - Tall, Haoua
AU - Halasa, Natasha
AU - Khuri-Bulos, Najwa
AU - Nokes, D. James
AU - Munywoki, Patrick K.
AU - Otieno, Grieven P.
AU - O'Brien, Katherine L.
AU - Oshitani, Katherine L.
AU - Da Costa Oliveira, Maria Tereza
AU - De Freitas Lázaro Emediato, Carla Cecília
AU - Ali, Asad
AU - Aamir, Uzma Bashir
AU - Noyola, Daniel E.
AU - Cohen, Cheryl
AU - Moyes, Jocelyn
AU - Giamberardino, Heloisa Ihle Garcia
AU - Obodai, Evangeline
AU - Odoom, John Kofi
N1 - Publisher Copyright:
© 2021 The Author(s). Published by Oxford University Press for the Infectious Diseases Society of America.
PY - 2021/9/1
Y1 - 2021/9/1
N2 - Background: Respiratory syncytial virus (RSV) is a leading cause of pediatric death, with >99% of mortality occurring in low- and lower middle-income countries. At least half of RSV-related deaths are estimated to occur in the community, but clinical characteristics of this group of children remain poorly characterized. Methods: The RSV Global Online Mortality Database (RSV GOLD), a global registry of under-5 children who have died with RSV-related illness, describes clinical characteristics of children dying of RSV through global data sharing. RSV GOLD acts as a collaborative platform for global deaths, including community mortality studies described in this supplement. We aimed to compare the age distribution of infant deaths <6 months occurring in the community with in-hospital. Results: We studied 829 RSV-related deaths <1 year of age from 38 developing countries, including 166 community deaths from 12 countries. There were 629 deaths that occurred <6 months, of which 156 (25%) occurred in the community. Among infants who died before 6 months of age, median age at death in the community (1.5 months; IQR: 0.8-3.3) was lower than in-hospital (2.4 months; IQR: 1.5-4.0; P<.0001). The proportion of neonatal deaths was higher in the community (29%, 46/156) than in-hospital (12%, 57/473, P<0.0001). Conclusions: We observed that children in the community die at a younger age. We expect that maternal vaccination or immunoprophylaxis against RSV will have a larger impact on RSV-related mortality in the community than in-hospital. This case series of RSV-related community deaths, made possible through global data sharing, allowed us to assess the potential impact of future RSV vaccines.
AB - Background: Respiratory syncytial virus (RSV) is a leading cause of pediatric death, with >99% of mortality occurring in low- and lower middle-income countries. At least half of RSV-related deaths are estimated to occur in the community, but clinical characteristics of this group of children remain poorly characterized. Methods: The RSV Global Online Mortality Database (RSV GOLD), a global registry of under-5 children who have died with RSV-related illness, describes clinical characteristics of children dying of RSV through global data sharing. RSV GOLD acts as a collaborative platform for global deaths, including community mortality studies described in this supplement. We aimed to compare the age distribution of infant deaths <6 months occurring in the community with in-hospital. Results: We studied 829 RSV-related deaths <1 year of age from 38 developing countries, including 166 community deaths from 12 countries. There were 629 deaths that occurred <6 months, of which 156 (25%) occurred in the community. Among infants who died before 6 months of age, median age at death in the community (1.5 months; IQR: 0.8-3.3) was lower than in-hospital (2.4 months; IQR: 1.5-4.0; P<.0001). The proportion of neonatal deaths was higher in the community (29%, 46/156) than in-hospital (12%, 57/473, P<0.0001). Conclusions: We observed that children in the community die at a younger age. We expect that maternal vaccination or immunoprophylaxis against RSV will have a larger impact on RSV-related mortality in the community than in-hospital. This case series of RSV-related community deaths, made possible through global data sharing, allowed us to assess the potential impact of future RSV vaccines.
KW - community death
KW - lower respiratory tract infection
KW - respiratory syncytial virus
UR - https://www.scopus.com/pages/publications/85115279177
U2 - 10.1093/cid/ciab528
DO - 10.1093/cid/ciab528
M3 - Article
C2 - 34472576
AN - SCOPUS:85115279177
SN - 1058-4838
VL - 73
SP - S229-S237
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
ER -
SDG 3 Good Health and Well-being