TY - JOUR
T1 - From nature's bounty to drug discovery
T2 - Leveraging phytochemicals and molecular approaches to combat multi-drug-resistant (MDR) tuberculosis
AU - Nalam, Sarveswara Mounik
AU - Chintamaneni, Pavan Kumar
AU - Saxena Pal, Rashmi
AU - Chaitanya, M. V.N.L.
AU - Kumar Singh, Sachin
AU - Saranya, P.
AU - Arora, Smriti
AU - Sharma, Sarika
AU - Pandey, Pratibha
AU - Mazumder, Avijit
AU - Babu, Ravindra
AU - Amoateng, Patrick
AU - Singh, Amandeep
N1 - Publisher Copyright:
© 2023 Tuberculosis Association of India
PY - 2023
Y1 - 2023
N2 - A large number of people annually lose their lives to tuberculosis (TB), which is an age-old disease caused by the Mycobacterium tuberculosis. The global spread of TB is a concern for all regions. The south-east Asian region recorded 46% of all new TB cases in 2021, followed by the African and western Pacific regions with 23% and 18%, respectively. Researchers are always searching at natural substances for potential alternative therapeutics to tackle the worrisome growth in multi-drug-resistant (MDR) tuberculosis due to the high costs associated with developing new treatments and unfavourable side effects of currently used synthetic pharmaceuticals. Phytochemicals show promising results as a future health aid due to their multi-targeting ability on pathogen cells. In the search for new drug leads, the Ayurvedic and Siddha medical systems have made an extensive use of ethnomedicinal tools, including the use of plants like Amalaki (Emblica officinalis Gaertn.), Guduchi (Tinospora cordifolia willd.), Sariva (Hemidesmus indicus R.Br.), Kustha (Saussurea lappa Falc.), turmeric (Curcuma longa Mal.) and Green tea (Camellia sinensis Linn.). These sources are high in flavonoids, polyphenols, tannins and catechins, has been shown to reduce the risk of TB. In this overview, we look at how natural sources like plants, algae and mushrooms have helped researchers to find new drug leads, and how to back these natural sources through mapping the molecular approaches and other approaches has helped them to defeat MDR.
AB - A large number of people annually lose their lives to tuberculosis (TB), which is an age-old disease caused by the Mycobacterium tuberculosis. The global spread of TB is a concern for all regions. The south-east Asian region recorded 46% of all new TB cases in 2021, followed by the African and western Pacific regions with 23% and 18%, respectively. Researchers are always searching at natural substances for potential alternative therapeutics to tackle the worrisome growth in multi-drug-resistant (MDR) tuberculosis due to the high costs associated with developing new treatments and unfavourable side effects of currently used synthetic pharmaceuticals. Phytochemicals show promising results as a future health aid due to their multi-targeting ability on pathogen cells. In the search for new drug leads, the Ayurvedic and Siddha medical systems have made an extensive use of ethnomedicinal tools, including the use of plants like Amalaki (Emblica officinalis Gaertn.), Guduchi (Tinospora cordifolia willd.), Sariva (Hemidesmus indicus R.Br.), Kustha (Saussurea lappa Falc.), turmeric (Curcuma longa Mal.) and Green tea (Camellia sinensis Linn.). These sources are high in flavonoids, polyphenols, tannins and catechins, has been shown to reduce the risk of TB. In this overview, we look at how natural sources like plants, algae and mushrooms have helped researchers to find new drug leads, and how to back these natural sources through mapping the molecular approaches and other approaches has helped them to defeat MDR.
KW - Ayurveda
KW - Mycobacterium tuberculosis
KW - Nanoparticles
KW - Natural resources
KW - Tuberculosis
UR - http://www.scopus.com/inward/record.url?scp=85170406595&partnerID=8YFLogxK
U2 - 10.1016/j.ijtb.2023.08.007
DO - 10.1016/j.ijtb.2023.08.007
M3 - Review article
AN - SCOPUS:85170406595
SN - 0019-5707
JO - Indian Journal of Tuberculosis
JF - Indian Journal of Tuberculosis
ER -