Fc gamma receptor 3B (FCGR3B-c.233C>A-rs5030738) polymorphism modifies the protective effect of malaria specific antibodies in ghanaian children

Bright Adu; Micha Phill Grønholm Jepsen; Thomas A. Gerds; Eric Kyei-Baafour; Michael Christiansen; Daniel Dodoo; Michael Theisen

doi:10.1093/infdis/jit422

Fc gamma receptor 3B (FCGR3B-c.233C>A-rs5030738) polymorphism modifies the protective effect of malaria specific antibodies in ghanaian children

Bright Adu, Micha Phill Grønholm Jepsen, Thomas A. Gerds, Eric Kyei-Baafour, Michael Christiansen, Daniel Dodoo, Michael Theisen

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Immunoglobulin G (IgG) cross-linking with Fc gamma receptor IIIB (FcγRIIIB) triggers neutrophil degranulation, releasing reactive oxygen species with high levels associated with protection against malaria. The FCGR3B-c.233C>A polymorphism thought to influence the interaction between IgG and FcγRIIIB was recently associated with malaria. We studied the statistical interaction between glutamate rich protein antibodies and FCGR3B-c.233C>A genotypes on risk of malaria in a cohort of Ghanaian children. The absolute risk of malaria decreased more rapidly with increasing antibody levels for 233AA/AC individuals compared with 233CC children. This genotype related effect modification may significantly influence malaria sero-epidemiological and vaccine trial studies.

Original language	English
Pages (from-to)	285-289
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	209
Issue number	2
DOIs	https://doi.org/10.1093/infdis/jit422
Publication status	Published - 15 Jan 2014
Externally published	Yes

Keywords

Effect modification
FCGR3B-c.233C>A
FcγRIIIB
GLURP
Malaria
Neutrophils
Plasmodium falciparum

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/infdis/jit422

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title = "Fc gamma receptor 3B (FCGR3B-c.233C>A-rs5030738) polymorphism modifies the protective effect of malaria specific antibodies in ghanaian children",

abstract = "Immunoglobulin G (IgG) cross-linking with Fc gamma receptor IIIB (FcγRIIIB) triggers neutrophil degranulation, releasing reactive oxygen species with high levels associated with protection against malaria. The FCGR3B-c.233C>A polymorphism thought to influence the interaction between IgG and FcγRIIIB was recently associated with malaria. We studied the statistical interaction between glutamate rich protein antibodies and FCGR3B-c.233C>A genotypes on risk of malaria in a cohort of Ghanaian children. The absolute risk of malaria decreased more rapidly with increasing antibody levels for 233AA/AC individuals compared with 233CC children. This genotype related effect modification may significantly influence malaria sero-epidemiological and vaccine trial studies.",

keywords = "Effect modification, FCGR3B-c.233C>A, FcγRIIIB, GLURP, Malaria, Neutrophils, Plasmodium falciparum",

author = "Bright Adu and Jepsen, \{Micha Phill Gr{\o}nholm\} and Gerds, \{Thomas A.\} and Eric Kyei-Baafour and Michael Christiansen and Daniel Dodoo and Michael Theisen",

year = "2014",

month = jan,

day = "15",

doi = "10.1093/infdis/jit422",

language = "English",

volume = "209",

pages = "285--289",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "2",

}

TY - JOUR

T1 - Fc gamma receptor 3B (FCGR3B-c.233C>A-rs5030738) polymorphism modifies the protective effect of malaria specific antibodies in ghanaian children

AU - Adu, Bright

AU - Jepsen, Micha Phill Grønholm

AU - Gerds, Thomas A.

AU - Kyei-Baafour, Eric

AU - Christiansen, Michael

AU - Dodoo, Daniel

AU - Theisen, Michael

PY - 2014/1/15

Y1 - 2014/1/15

N2 - Immunoglobulin G (IgG) cross-linking with Fc gamma receptor IIIB (FcγRIIIB) triggers neutrophil degranulation, releasing reactive oxygen species with high levels associated with protection against malaria. The FCGR3B-c.233C>A polymorphism thought to influence the interaction between IgG and FcγRIIIB was recently associated with malaria. We studied the statistical interaction between glutamate rich protein antibodies and FCGR3B-c.233C>A genotypes on risk of malaria in a cohort of Ghanaian children. The absolute risk of malaria decreased more rapidly with increasing antibody levels for 233AA/AC individuals compared with 233CC children. This genotype related effect modification may significantly influence malaria sero-epidemiological and vaccine trial studies.

AB - Immunoglobulin G (IgG) cross-linking with Fc gamma receptor IIIB (FcγRIIIB) triggers neutrophil degranulation, releasing reactive oxygen species with high levels associated with protection against malaria. The FCGR3B-c.233C>A polymorphism thought to influence the interaction between IgG and FcγRIIIB was recently associated with malaria. We studied the statistical interaction between glutamate rich protein antibodies and FCGR3B-c.233C>A genotypes on risk of malaria in a cohort of Ghanaian children. The absolute risk of malaria decreased more rapidly with increasing antibody levels for 233AA/AC individuals compared with 233CC children. This genotype related effect modification may significantly influence malaria sero-epidemiological and vaccine trial studies.

KW - Effect modification

KW - FCGR3B-c.233C>A

KW - FcγRIIIB

KW - GLURP

KW - Malaria

KW - Neutrophils

KW - Plasmodium falciparum

UR - https://www.scopus.com/pages/publications/84891512092

U2 - 10.1093/infdis/jit422

DO - 10.1093/infdis/jit422

M3 - Article

AN - SCOPUS:84891512092

SN - 0022-1899

VL - 209

SP - 285

EP - 289

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 2

ER -

Fc gamma receptor 3B (FCGR3B-c.233C>A-rs5030738) polymorphism modifies the protective effect of malaria specific antibodies in ghanaian children

Abstract

Keywords

UN SDGs

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