Fc gamma receptor 3B (FCGR3B-c.233C>A-rs5030738) polymorphism modifies the protective effect of malaria specific antibodies in ghanaian children

Bright Adu, Micha Phill Grønholm Jepsen, Thomas A. Gerds, Eric Kyei-Baafour, Michael Christiansen, Daniel Dodoo, Michael Theisen

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

Immunoglobulin G (IgG) cross-linking with Fc gamma receptor IIIB (FcγRIIIB) triggers neutrophil degranulation, releasing reactive oxygen species with high levels associated with protection against malaria. The FCGR3B-c.233C>A polymorphism thought to influence the interaction between IgG and FcγRIIIB was recently associated with malaria. We studied the statistical interaction between glutamate rich protein antibodies and FCGR3B-c.233C>A genotypes on risk of malaria in a cohort of Ghanaian children. The absolute risk of malaria decreased more rapidly with increasing antibody levels for 233AA/AC individuals compared with 233CC children. This genotype related effect modification may significantly influence malaria sero-epidemiological and vaccine trial studies.

Original languageEnglish
Pages (from-to)285-289
Number of pages5
JournalJournal of Infectious Diseases
Volume209
Issue number2
DOIs
Publication statusPublished - 15 Jan 2014
Externally publishedYes

Keywords

  • Effect modification
  • FCGR3B-c.233C>A
  • FcγRIIIB
  • GLURP
  • Malaria
  • Neutrophils
  • Plasmodium falciparum

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