Expression of variant surface antigens by Plasmodium falciparum parasites in the peripheral blood of clinically immune pregnant women indicates ongoing placental infection

Michael F. Ofori; Trine Staalsoe; Victoria Bam; Maja Lundquist; Kim P. David; Edmund N.L. Browne; Bartholomew D. Akanmori; Lars Hviid

doi:10.1128/IAI.71.3.1584-1586.2003

Expression of variant surface antigens by Plasmodium falciparum parasites in the peripheral blood of clinically immune pregnant women indicates ongoing placental infection

Michael F. Ofori
, Trine Staalsoe
, Victoria Bam
, Maja Lundquist
, Kim P. David
, Edmund N.L. Browne
, Bartholomew D. Akanmori
, Lars Hviid

Department of Immunology

University of Copenhagen
Kwame Nkrumah University of Science and Technology
University of Ghana
Rigshospitalet

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

Placenta-sequestered Plasmodium falciparum parasites that cause pregnancy-associated malaria (PAM) in otherwise clinically immune women express distinct variant surface antigens (VSA_PAM) not expressed by parasites in nonpregnant individuals. We report here that parasites from the peripheral blood of clinically immune pregnant women also express VSA_PAM, making them a convenient source of VSA_PAM expressors for PAM vaccine research.

Original language	English
Pages (from-to)	1584-1586
Number of pages	3
Journal	Infection and Immunity
Volume	71
Issue number	3
DOIs	https://doi.org/10.1128/IAI.71.3.1584-1586.2003
Publication status	Published - 1 Mar 2003

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SDG 3 Good Health and Well-being

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10.1128/IAI.71.3.1584-1586.2003

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Ofori, M. F., Staalsoe, T., Bam, V., Lundquist, M., David, K. P., Browne, E. N. L., Akanmori, B. D., & Hviid, L. (2003). Expression of variant surface antigens by Plasmodium falciparum parasites in the peripheral blood of clinically immune pregnant women indicates ongoing placental infection. Infection and Immunity, 71(3), 1584-1586. https://doi.org/10.1128/IAI.71.3.1584-1586.2003

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abstract = "Placenta-sequestered Plasmodium falciparum parasites that cause pregnancy-associated malaria (PAM) in otherwise clinically immune women express distinct variant surface antigens (VSAPAM) not expressed by parasites in nonpregnant individuals. We report here that parasites from the peripheral blood of clinically immune pregnant women also express VSAPAM, making them a convenient source of VSAPAM expressors for PAM vaccine research.",

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Ofori, MF, Staalsoe, T, Bam, V, Lundquist, M, David, KP, Browne, ENL, Akanmori, BD & Hviid, L 2003, 'Expression of variant surface antigens by Plasmodium falciparum parasites in the peripheral blood of clinically immune pregnant women indicates ongoing placental infection', Infection and Immunity, vol. 71, no. 3, pp. 1584-1586. https://doi.org/10.1128/IAI.71.3.1584-1586.2003

TY - JOUR

T1 - Expression of variant surface antigens by Plasmodium falciparum parasites in the peripheral blood of clinically immune pregnant women indicates ongoing placental infection

AU - Ofori, Michael F.

AU - Staalsoe, Trine

AU - Bam, Victoria

AU - Lundquist, Maja

AU - David, Kim P.

AU - Browne, Edmund N.L.

AU - Akanmori, Bartholomew D.

AU - Hviid, Lars

PY - 2003/3/1

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N2 - Placenta-sequestered Plasmodium falciparum parasites that cause pregnancy-associated malaria (PAM) in otherwise clinically immune women express distinct variant surface antigens (VSAPAM) not expressed by parasites in nonpregnant individuals. We report here that parasites from the peripheral blood of clinically immune pregnant women also express VSAPAM, making them a convenient source of VSAPAM expressors for PAM vaccine research.

AB - Placenta-sequestered Plasmodium falciparum parasites that cause pregnancy-associated malaria (PAM) in otherwise clinically immune women express distinct variant surface antigens (VSAPAM) not expressed by parasites in nonpregnant individuals. We report here that parasites from the peripheral blood of clinically immune pregnant women also express VSAPAM, making them a convenient source of VSAPAM expressors for PAM vaccine research.

UR - https://www.scopus.com/pages/publications/0037369836

U2 - 10.1128/IAI.71.3.1584-1586.2003

DO - 10.1128/IAI.71.3.1584-1586.2003

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AN - SCOPUS:0037369836

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JO - Infection and Immunity

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IS - 3

ER -

Expression of variant surface antigens by Plasmodium falciparum parasites in the peripheral blood of clinically immune pregnant women indicates ongoing placental infection

Abstract

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