Expression of variant surface antigens by Plasmodium falciparum parasites in the peripheral blood of clinically immune pregnant women indicates ongoing placental infection

Michael F. Ofori, Trine Staalsoe, Victoria Bam, Maja Lundquist, Kim P. David, Edmund N.L. Browne, Bartholomew D. Akanmori, Lars Hviid

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

Placenta-sequestered Plasmodium falciparum parasites that cause pregnancy-associated malaria (PAM) in otherwise clinically immune women express distinct variant surface antigens (VSAPAM) not expressed by parasites in nonpregnant individuals. We report here that parasites from the peripheral blood of clinically immune pregnant women also express VSAPAM, making them a convenient source of VSAPAM expressors for PAM vaccine research.

Original languageEnglish
Pages (from-to)1584-1586
Number of pages3
JournalInfection and Immunity
Volume71
Issue number3
DOIs
Publication statusPublished - 1 Mar 2003
Externally publishedYes

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