TY - JOUR
T1 - Experiences and challenges in the management of pregnancy-associated breast cancer at the Korle Bu Teaching Hospital
T2 - A review of four cases
AU - Nsaful, Josephine
AU - Vanderpuye, Verna
AU - Scott, Aba Anoa
AU - Dedey, Florence
AU - Oppong, Samuel A.
AU - Appiah-Danquah, Rita
AU - Damale, Nelson
AU - Fenu, Benjamin
AU - Wordui, Theodore
AU - Yarney, Joel
AU - Clegg-Lamptey, Joe Nat
N1 - Publisher Copyright:
© 2020 ecancer Global Foundation. All rights reserved.
PY - 2020
Y1 - 2020
N2 - Breast cancer is the commonest female cancer worldwide and the most common malignancy during pregnancy. The current management of breast cancer is based on patient and tumour characteristics, preferences and disease stage. In pregnancy-associated breast cancer, the gestational age influences treatment options. Sequencing of therapies is guided by safe imaging options, timing of delivery and prognosis. Systemic therapy options in the neoadjuvant, adjuvant and palliative settings are limited due to safety concerns of the unborn foetus. In resource-constrained regions, the application of safe options may be challenging. This paper reports four of such cases managed in Ghana using a multidisciplinary approach and local resource-appropriate evidence-based practices. Maternal and foetal outcomes were acceptable with none resulting in termination of pregnancy.
AB - Breast cancer is the commonest female cancer worldwide and the most common malignancy during pregnancy. The current management of breast cancer is based on patient and tumour characteristics, preferences and disease stage. In pregnancy-associated breast cancer, the gestational age influences treatment options. Sequencing of therapies is guided by safe imaging options, timing of delivery and prognosis. Systemic therapy options in the neoadjuvant, adjuvant and palliative settings are limited due to safety concerns of the unborn foetus. In resource-constrained regions, the application of safe options may be challenging. This paper reports four of such cases managed in Ghana using a multidisciplinary approach and local resource-appropriate evidence-based practices. Maternal and foetal outcomes were acceptable with none resulting in termination of pregnancy.
KW - Gestational breast cancer
KW - Multidisciplinary team
KW - Pregnancy-associated breast cancer
UR - http://www.scopus.com/inward/record.url?scp=85097024242&partnerID=8YFLogxK
U2 - 10.3332/ECANCER.2020.1140
DO - 10.3332/ECANCER.2020.1140
M3 - Article
AN - SCOPUS:85097024242
SN - 1754-6605
VL - 14
JO - ecancermedicalscience
JF - ecancermedicalscience
M1 - 1140
ER -