Evidence of henipavirus infection in West African fruit bats

David T.S. Hayman; Richard Suu-Ire; Andrew C. Breed; Jennifer A. McEachern; Linfa Wang; James L.N. Wood; Andrew A. Cunningham

doi:10.1371/journal.pone.0002739

Evidence of henipavirus infection in West African fruit bats

David T.S. Hayman, Richard Suu-Ire, Andrew C. Breed, Jennifer A. McEachern, Linfa Wang, James L.N. Wood, Andrew A. Cunningham

Research output: Contribution to journal › Article › peer-review

200 Citations (Scopus)

Abstract

Henipaviruses are emerging RNA viruses of fruit bat origin that can cause fatal encephalitis in man. Ghanaian fruit bats (megachiroptera) were tested for antibodies to henipaviruses. Using a Luminex multiplexed microsphere assay, antibodies were detected in sera of Eidolon helvum to both Nipah (39%, 95% confidence interval: 27-51%) and Hendra (22%, 95% CI: 11-33%) viruses. Virus neutralization tests further confirmed seropositivity for 30% (7/23) of Luminex positive serum samples. Our results indicate that henipavirus is present within West Africa.

Original language	English
Article number	e2739
Journal	PLoS ONE
Volume	3
Issue number	7
DOIs	https://doi.org/10.1371/journal.pone.0002739
Publication status	Published - 23 Jul 2008
Externally published	Yes

Access to Document

10.1371/journal.pone.0002739

Cite this

@article{6c0db8569c1f4b40b3d1a6af97dca35a,

title = "Evidence of henipavirus infection in West African fruit bats",

abstract = "Henipaviruses are emerging RNA viruses of fruit bat origin that can cause fatal encephalitis in man. Ghanaian fruit bats (megachiroptera) were tested for antibodies to henipaviruses. Using a Luminex multiplexed microsphere assay, antibodies were detected in sera of Eidolon helvum to both Nipah (39%, 95% confidence interval: 27-51%) and Hendra (22%, 95% CI: 11-33%) viruses. Virus neutralization tests further confirmed seropositivity for 30% (7/23) of Luminex positive serum samples. Our results indicate that henipavirus is present within West Africa.",

author = "Hayman, {David T.S.} and Richard Suu-Ire and Breed, {Andrew C.} and McEachern, {Jennifer A.} and Linfa Wang and Wood, {James L.N.} and Cunningham, {Andrew A.}",

year = "2008",

month = jul,

day = "23",

doi = "10.1371/journal.pone.0002739",

language = "English",

volume = "3",

journal = "PLoS ONE",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "7",

}

TY - JOUR

T1 - Evidence of henipavirus infection in West African fruit bats

AU - Hayman, David T.S.

AU - Suu-Ire, Richard

AU - Breed, Andrew C.

AU - McEachern, Jennifer A.

AU - Wang, Linfa

AU - Wood, James L.N.

AU - Cunningham, Andrew A.

PY - 2008/7/23

Y1 - 2008/7/23

N2 - Henipaviruses are emerging RNA viruses of fruit bat origin that can cause fatal encephalitis in man. Ghanaian fruit bats (megachiroptera) were tested for antibodies to henipaviruses. Using a Luminex multiplexed microsphere assay, antibodies were detected in sera of Eidolon helvum to both Nipah (39%, 95% confidence interval: 27-51%) and Hendra (22%, 95% CI: 11-33%) viruses. Virus neutralization tests further confirmed seropositivity for 30% (7/23) of Luminex positive serum samples. Our results indicate that henipavirus is present within West Africa.

AB - Henipaviruses are emerging RNA viruses of fruit bat origin that can cause fatal encephalitis in man. Ghanaian fruit bats (megachiroptera) were tested for antibodies to henipaviruses. Using a Luminex multiplexed microsphere assay, antibodies were detected in sera of Eidolon helvum to both Nipah (39%, 95% confidence interval: 27-51%) and Hendra (22%, 95% CI: 11-33%) viruses. Virus neutralization tests further confirmed seropositivity for 30% (7/23) of Luminex positive serum samples. Our results indicate that henipavirus is present within West Africa.

UR - http://www.scopus.com/inward/record.url?scp=50549098494&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0002739

DO - 10.1371/journal.pone.0002739

M3 - Article

C2 - 18648649

AN - SCOPUS:50549098494

SN - 1932-6203

VL - 3

JO - PLoS ONE

JF - PLoS ONE

IS - 7

M1 - e2739

ER -

Evidence of henipavirus infection in West African fruit bats

Abstract

Access to Document

Other files and links

Fingerprint

Cite this