Abstract
(Chemical Equation Presented) The iron-y of fate: Isobole analyses of fluorescently labeled antimalarial endoperoxides with chelators selective for non-heme iron, and laser confocal microscopy studies within living malaria parasites have shown that the semisynthetic analogues of artemisinin and synthetic endoperoxides (see example) share a common mechanism of action involving chelatable-iron-mediated bioactivation (see images) and irreversible alkylation of parasite targets.
Original language | English |
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Pages (from-to) | 6278-6283 |
Number of pages | 6 |
Journal | Angewandte Chemie - International Edition |
Volume | 46 |
Issue number | 33 |
DOIs | |
Publication status | Published - 2007 |
Externally published | Yes |
Keywords
- Antimalarial agents
- Chelates
- Confocal imaging
- Fluorescence
- Iron