TY - JOUR
T1 - EUS-guided ethanol ablation in patients with solid pseudopapillary neoplasm
T2 - a four-case series
AU - Myung, Yousik
AU - Hara, Kazuo
AU - Haba, Shin
AU - Kuwahara, Takamichi
AU - Okuno, Nozomi
AU - Koda, Hiroki
AU - Melianti, Indria
AU - Agyei-Nkansah, Adwoa
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Japanese Society of Gastroenterology 2025.
PY - 2025/8
Y1 - 2025/8
N2 - Background/aims: Solid pseudopapillary neoplasm (SPN) of the pancreas is a rare tumor with low malignant potential, though 10–15% may show invasive or metastatic behavior. This study aimed to evaluate the safety and efficacy of endoscopic ultrasound-guided ethanol ablation (EUS-EI) in patients with SPN who were not surgical candidates. Methods: Four patients with SPN who declined or were ineligible for surgery underwent EUS-EI at Aichi Cancer Center. Technical and clinical outcomes, as well as adverse events, were assessed. Results: Technical success was achieved in all patients (100%). Clinical success was observed in three patients (75%), including two with complete ablation and one with significant tumor reduction. No major adverse events or tumor recurrence occurred during follow-up. Conclusions: EUS-EI may be a safe and effective alternative for managing SPN in non-surgical candidates.
AB - Background/aims: Solid pseudopapillary neoplasm (SPN) of the pancreas is a rare tumor with low malignant potential, though 10–15% may show invasive or metastatic behavior. This study aimed to evaluate the safety and efficacy of endoscopic ultrasound-guided ethanol ablation (EUS-EI) in patients with SPN who were not surgical candidates. Methods: Four patients with SPN who declined or were ineligible for surgery underwent EUS-EI at Aichi Cancer Center. Technical and clinical outcomes, as well as adverse events, were assessed. Results: Technical success was achieved in all patients (100%). Clinical success was observed in three patients (75%), including two with complete ablation and one with significant tumor reduction. No major adverse events or tumor recurrence occurred during follow-up. Conclusions: EUS-EI may be a safe and effective alternative for managing SPN in non-surgical candidates.
KW - Endoscopic ultrasound
KW - Ethanol ablation
KW - Minimally invasive therapy
KW - Pancreatic tumor
KW - Solid pseudopapillary neoplasm
UR - https://www.scopus.com/pages/publications/105008918763
U2 - 10.1007/s12328-025-02163-6
DO - 10.1007/s12328-025-02163-6
M3 - Article
AN - SCOPUS:105008918763
SN - 1865-7257
VL - 18
SP - 767
EP - 772
JO - Clinical Journal of Gastroenterology
JF - Clinical Journal of Gastroenterology
IS - 4
ER -
