Effective vaccine safety systems in all countries: A challenge for more equitable access to immunization

Ananda Amarasinghe, Steve Black, Jan Bonhoeffer, Sandra M.Deotti Carvalho, Alexander Dodoo, Juhani Eskola, Heidi Larson, Sunheang Shin, Sten Olsson, Madhava Ram Balakrishnan, Ahmed Bellah, Philipp Lambach, Christine Maure, David Wood, Patrick Zuber, Bartholomew Akanmori, Pamela Bravo, María Pombo, Houda Langar, Dina PfeiferStéphane Guichard, Sergey Diorditsa, Md Shafiqul Hossain, Yoshikuni Sato

Research output: Contribution to journalReview articlepeer-review

37 Citations (Scopus)

Abstract

Serious vaccine-associated adverse events are rare. To further minimize their occurrence and to provide adequate care to those affected, careful monitoring of immunization programs and case management is required. Unfounded vaccine safety concerns have the potential of seriously derailing effective immunization activities. To address these issues, vaccine pharmacovigilance systems have been developed in many industrialized countries. As new vaccine products become available to prevent new diseases in various parts of the world, the demand for effective pharmacovigilance systems in low- and middle-income countries (LMIC) is increasing.To help establish such systems in all countries, WHO developed the Global Vaccine Safety Blueprint in 2011. This strategic plan is based on an in-depth analysis of the vaccine safety landscape that involved many stakeholders. This analysis reviewed existing systems and international vaccine safety activities and assessed the financial resources required to operate them. The Blueprint sets three main strategic goals to optimize the safety of vaccines through effective use of pharmacovigilance principles and methods: to ensure minimal vaccine safety capacity in all countries; to provide enhanced capacity for specific circumstances; and to establish a global support network to assist national authorities with capacity building and crisis management.

Original languageEnglish
Pages (from-to)B108-B114
JournalVaccine
Volume31
Issue numberSUPPL2
DOIs
Publication statusPublished - 18 Apr 2013

Keywords

  • Blueprint
  • Global Vaccine Safety
  • Global Vaccine Safety Initiative
  • GVSI
  • Immunization safety
  • Post marketing surveillance
  • Vaccine Safety

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