Effect of Ochratoxin A (OTA) on the Immune System: A Systematic Review

Yusif Mubarik; Shadrach Tetteh Boyetey; Anastasia Rosebud Aikins; Mohamed Mutocheluh

doi:10.3390/toxins17050256

Effect of Ochratoxin A (OTA) on the Immune System: A Systematic Review

Yusif Mubarik
, Shadrach Tetteh Boyetey
, Anastasia Rosebud Aikins
, Mohamed Mutocheluh

Department of Biochemistry, Cell And Molecular Biology

Research output: Contribution to journal › Review article › peer-review

3 Citations (Scopus)

Abstract

Ochratoxin A (OTA) is a mycotoxin with different adverse health effects. The authors conducted a systematic review to evaluate the effects of OTA on the immune system, with more emphasis on its effects on immune system organs, innate and adaptive immunity and related signaling pathways. Studies have demonstrated that exposure to OTA disrupts the functions of immune system organs, resulting in weight loss, histological lesions and a decrease in antibody-secreting cells. There is evidence that OTA impairs epithelial barrier integrity and macrophage function and induces elevated secretion of pro-inflammatory cytokines. In adaptive immunity, OTA regulates T-cell differentiation, particularly Th1 and Th17 subsets, and adversely impacts humoral immunity, ultimately leading to immune suppression.

Original language	English
Article number	256
Journal	Toxins
Volume	17
Issue number	5
DOIs	https://doi.org/10.3390/toxins17050256
Publication status	Published - May 2025

Keywords

adaptive
immunity
innate
ochratoxin A (OTA)

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10.3390/toxins17050256

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abstract = "Ochratoxin A (OTA) is a mycotoxin with different adverse health effects. The authors conducted a systematic review to evaluate the effects of OTA on the immune system, with more emphasis on its effects on immune system organs, innate and adaptive immunity and related signaling pathways. Studies have demonstrated that exposure to OTA disrupts the functions of immune system organs, resulting in weight loss, histological lesions and a decrease in antibody-secreting cells. There is evidence that OTA impairs epithelial barrier integrity and macrophage function and induces elevated secretion of pro-inflammatory cytokines. In adaptive immunity, OTA regulates T-cell differentiation, particularly Th1 and Th17 subsets, and adversely impacts humoral immunity, ultimately leading to immune suppression.",

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AU - Mubarik, Yusif

AU - Boyetey, Shadrach Tetteh

AU - Aikins, Anastasia Rosebud

AU - Mutocheluh, Mohamed

PY - 2025/5

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N2 - Ochratoxin A (OTA) is a mycotoxin with different adverse health effects. The authors conducted a systematic review to evaluate the effects of OTA on the immune system, with more emphasis on its effects on immune system organs, innate and adaptive immunity and related signaling pathways. Studies have demonstrated that exposure to OTA disrupts the functions of immune system organs, resulting in weight loss, histological lesions and a decrease in antibody-secreting cells. There is evidence that OTA impairs epithelial barrier integrity and macrophage function and induces elevated secretion of pro-inflammatory cytokines. In adaptive immunity, OTA regulates T-cell differentiation, particularly Th1 and Th17 subsets, and adversely impacts humoral immunity, ultimately leading to immune suppression.

AB - Ochratoxin A (OTA) is a mycotoxin with different adverse health effects. The authors conducted a systematic review to evaluate the effects of OTA on the immune system, with more emphasis on its effects on immune system organs, innate and adaptive immunity and related signaling pathways. Studies have demonstrated that exposure to OTA disrupts the functions of immune system organs, resulting in weight loss, histological lesions and a decrease in antibody-secreting cells. There is evidence that OTA impairs epithelial barrier integrity and macrophage function and induces elevated secretion of pro-inflammatory cytokines. In adaptive immunity, OTA regulates T-cell differentiation, particularly Th1 and Th17 subsets, and adversely impacts humoral immunity, ultimately leading to immune suppression.

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KW - immunity

KW - innate

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M3 - Review article

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JO - Toxins

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ER -

Effect of Ochratoxin A (OTA) on the Immune System: A Systematic Review

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