Drug resistance problems in chemotherapy

Seth Kwabena Amponsah; Ismaila Adams

doi:10.1016/B978-0-323-90773-6.00024-5

Drug resistance problems in chemotherapy

Seth Kwabena Amponsah, Ismaila Adams

Department of Medical Pharmacology

University of Ghana

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Citations (Scopus)

Abstract

Drug resistance can be said to be one of the main causes of treatment failure in cancer. Through various mechanisms, malignant cells rapidly develop resistance to chemotherapeutic agents. Additionally, the problem of drug resistance appears to have affected the quest to develop new anticancer drugs. To improve chemotherapy and identify specific targets for new drugs, it is imperative to understand the various mechanisms of drug resistance. This chapter gives an insight into the pharmacokinetic, pharmacodynamic and pharmacogenomic factors that cause drug resistance in chemotherapy. Furthermore, factors to consider in discovery and development of new chemotherapeutic agents are also discussed.

Original language	English
Title of host publication	Nanocarriers for Drug-Targeting Brain Tumors
Publisher	Elsevier
Pages	121-141
Number of pages	21
ISBN (Electronic)	9780323907736
ISBN (Print)	9780323914710
DOIs	https://doi.org/10.1016/B978-0-323-90773-6.00024-5
Publication status	Published - 1 Jan 2022

Keywords

Cancer vaccines
Chemotherapy
Discovery
Drug resistance
Radiation therapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/B978-0-323-90773-6.00024-5

Cite this

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title = "Drug resistance problems in chemotherapy",

abstract = "Drug resistance can be said to be one of the main causes of treatment failure in cancer. Through various mechanisms, malignant cells rapidly develop resistance to chemotherapeutic agents. Additionally, the problem of drug resistance appears to have affected the quest to develop new anticancer drugs. To improve chemotherapy and identify specific targets for new drugs, it is imperative to understand the various mechanisms of drug resistance. This chapter gives an insight into the pharmacokinetic, pharmacodynamic and pharmacogenomic factors that cause drug resistance in chemotherapy. Furthermore, factors to consider in discovery and development of new chemotherapeutic agents are also discussed.",

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AU - Adams, Ismaila

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AB - Drug resistance can be said to be one of the main causes of treatment failure in cancer. Through various mechanisms, malignant cells rapidly develop resistance to chemotherapeutic agents. Additionally, the problem of drug resistance appears to have affected the quest to develop new anticancer drugs. To improve chemotherapy and identify specific targets for new drugs, it is imperative to understand the various mechanisms of drug resistance. This chapter gives an insight into the pharmacokinetic, pharmacodynamic and pharmacogenomic factors that cause drug resistance in chemotherapy. Furthermore, factors to consider in discovery and development of new chemotherapeutic agents are also discussed.

KW - Cancer vaccines

KW - Chemotherapy

KW - Discovery

KW - Drug resistance

KW - Radiation therapy

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M3 - Chapter

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SN - 9780323914710

SP - 121

EP - 141

BT - Nanocarriers for Drug-Targeting Brain Tumors

PB - Elsevier

ER -

Drug resistance problems in chemotherapy

Abstract

Keywords

UN SDGs

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