Drug Absorption via the Nasal Route: Opportunities and Challenges

Seth Kwabena Amponsah, Ismaila Adams

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

3 Citations (Scopus)

Abstract

Drug administration via the nasal route appears to be another reliable way of getting drugs into systemic circulation. The nasal route has easy access, large surface area, is well vascularized, and circumvents first-pass metabolism. Currently, there is a lot of attention on nasal delivery of drugs. This route has been found to aid rapid absorption of drugs into systemic circulation. The mucosa found in the nasal cavity has been shown to aid absorption of bioadhesive drug delivery devices. Microspheres, liposomes, and gels expand readily when they come into contact with the mucosa in the nasal cavity. Furthermore, to enhance absorption of drugs, a number of methods have been used to extend residence time in the nasal cavity. However, prospects of using the nasal route as a means of getting drugs into systemic circulation face a number of challenges. Some of which include barriers in the mucosa and toxicity which may be associated with the excipients used. Drug absorption enhancers are currently being explored to improve intranasal drug delivery. Drug absorption via the nasal route (opportunities and challenges) is discussed in this chapter.

Original languageEnglish
Title of host publicationNasal Drug Delivery
Subtitle of host publicationFormulations, Developments, Challenges, and Solutions
PublisherSpringer International Publishing
Pages25-42
Number of pages18
ISBN (Electronic)9783031231124
ISBN (Print)9783031231117
DOIs
Publication statusPublished - 1 Jan 2023

Keywords

  • Absorption
  • Challenges
  • Enzyme inhibitors
  • Nasal route
  • Surfactants

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