Differential constituents in roots, stems and leaves of Newbouldia laevis Thunb. screened by LC/ESI-Q-TOF-MS

Affo Dermane; Kafui Kpegba; Kodjo Eloh; Dorcas Osei-Safo; Richard K. Amewu; Pierluigi Caboni

doi:10.1016/j.rechem.2020.100052

Differential constituents in roots, stems and leaves of Newbouldia laevis Thunb. screened by LC/ESI-Q-TOF-MS

Affo Dermane, Kafui Kpegba, Kodjo Eloh, Dorcas Osei-Safo, Richard K. Amewu, Pierluigi Caboni

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Newbouldia laevis (P. Beauv.) Seem. or “Boundary Tree” is a medium sized angiosperm in the Bignoniaceae family. It is native to tropical Africa, especially used in West Africa to mark property boundaries in rural areas. Despite its intensive use in folk medicine, the plant chemical composition is under investigated. The study is aimed at identifying the chemical constituents of N. laevis crude plant extracts by high-performance liquid chromatography (HPLC) on line with an untargeted high-resolution mass spectrometry. The used HPLC method showed to be suitable for the determination of withasomnine, newbouldine, and lapachol derivatives together with other known bioactive compounds like phytosterols and triterpenoids. The importance of these chemical constituents is discussed with respect to the role of N. laevis in West African ethnomedicine.

Original language	English
Article number	100052
Journal	Results in Chemistry
Volume	2
DOIs	https://doi.org/10.1016/j.rechem.2020.100052
Publication status	Published - Jan 2020

Keywords

Antimalarial compound
Antitumor natural substances
LC-MS
Newbouldia laevis
Phytochemistry

Access to Document

10.1016/j.rechem.2020.100052

Cite this

@article{2a3126f9d2dc4f9f81a6254dbd5b8736,

title = "Differential constituents in roots, stems and leaves of Newbouldia laevis Thunb. screened by LC/ESI-Q-TOF-MS",

abstract = "Newbouldia laevis (P. Beauv.) Seem. or “Boundary Tree” is a medium sized angiosperm in the Bignoniaceae family. It is native to tropical Africa, especially used in West Africa to mark property boundaries in rural areas. Despite its intensive use in folk medicine, the plant chemical composition is under investigated. The study is aimed at identifying the chemical constituents of N. laevis crude plant extracts by high-performance liquid chromatography (HPLC) on line with an untargeted high-resolution mass spectrometry. The used HPLC method showed to be suitable for the determination of withasomnine, newbouldine, and lapachol derivatives together with other known bioactive compounds like phytosterols and triterpenoids. The importance of these chemical constituents is discussed with respect to the role of N. laevis in West African ethnomedicine.",

keywords = "Antimalarial compound, Antitumor natural substances, LC-MS, Newbouldia laevis, Phytochemistry",

author = "Affo Dermane and Kafui Kpegba and Kodjo Eloh and Dorcas Osei-Safo and Amewu, {Richard K.} and Pierluigi Caboni",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors",

year = "2020",

month = jan,

doi = "10.1016/j.rechem.2020.100052",

language = "English",

volume = "2",

journal = "Results in Chemistry",

issn = "2211-7156",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Differential constituents in roots, stems and leaves of Newbouldia laevis Thunb. screened by LC/ESI-Q-TOF-MS

AU - Dermane, Affo

AU - Kpegba, Kafui

AU - Eloh, Kodjo

AU - Osei-Safo, Dorcas

AU - Amewu, Richard K.

AU - Caboni, Pierluigi

PY - 2020/1

Y1 - 2020/1

N2 - Newbouldia laevis (P. Beauv.) Seem. or “Boundary Tree” is a medium sized angiosperm in the Bignoniaceae family. It is native to tropical Africa, especially used in West Africa to mark property boundaries in rural areas. Despite its intensive use in folk medicine, the plant chemical composition is under investigated. The study is aimed at identifying the chemical constituents of N. laevis crude plant extracts by high-performance liquid chromatography (HPLC) on line with an untargeted high-resolution mass spectrometry. The used HPLC method showed to be suitable for the determination of withasomnine, newbouldine, and lapachol derivatives together with other known bioactive compounds like phytosterols and triterpenoids. The importance of these chemical constituents is discussed with respect to the role of N. laevis in West African ethnomedicine.

AB - Newbouldia laevis (P. Beauv.) Seem. or “Boundary Tree” is a medium sized angiosperm in the Bignoniaceae family. It is native to tropical Africa, especially used in West Africa to mark property boundaries in rural areas. Despite its intensive use in folk medicine, the plant chemical composition is under investigated. The study is aimed at identifying the chemical constituents of N. laevis crude plant extracts by high-performance liquid chromatography (HPLC) on line with an untargeted high-resolution mass spectrometry. The used HPLC method showed to be suitable for the determination of withasomnine, newbouldine, and lapachol derivatives together with other known bioactive compounds like phytosterols and triterpenoids. The importance of these chemical constituents is discussed with respect to the role of N. laevis in West African ethnomedicine.

KW - Antimalarial compound

KW - Antitumor natural substances

KW - LC-MS

KW - Newbouldia laevis

KW - Phytochemistry

UR - http://www.scopus.com/inward/record.url?scp=85095941676&partnerID=8YFLogxK

U2 - 10.1016/j.rechem.2020.100052

DO - 10.1016/j.rechem.2020.100052

M3 - Article

AN - SCOPUS:85095941676

SN - 2211-7156

VL - 2

JO - Results in Chemistry

JF - Results in Chemistry

M1 - 100052

ER -

Differential constituents in roots, stems and leaves of Newbouldia laevis Thunb. screened by LC/ESI-Q-TOF-MS

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this