TY - JOUR
T1 - Depression in Sub-Saharan Africa
AU - Gbadamosi, Ismail Temitayo
AU - Henneh, Isaac Tabiri
AU - Aluko, Oritoke Modupe
AU - Yawson, Emmanuel Olusola
AU - Fokoua, Aliance Romain
AU - Koomson, Awo
AU - Torbi, Joseph
AU - Olorunnado, Samson Ehindero
AU - Lewu, Folashade Susan
AU - Yusha'u, Yusuf
AU - Keji-Taofik, Salmat Temilola
AU - Biney, Robert Peter
AU - Tagoe, Thomas Amatey
N1 - Publisher Copyright:
© 2022 The Authors
PY - 2022/6
Y1 - 2022/6
N2 - Mood disorders can be considered among the most common and debilitating mental disorders. Major depression, as an example of mood disorders, is known to severely reduce the quality of life as well as psychosocial functioning of those affected. Its impact on the burden of disease worldwide has been enormous, with the World Health Organisation projecting depression to be the leading cause of mental illness by 2030. Despite several studies on the subject, little has been done to contextualise the condition in Africa, coupled with the fact that there is still much to be understood on the subject. This review attempts to shed more light on the prevalence of depression in Sub-Saharan Africa (SSA), its pathophysiology, risk factors, diagnosis and the experimental models available to study depression within the sub-region. It also evaluates the contribution of the sub-region to the global research output of depression as well as bottlenecks associated with full exploitation of the sub region's resources to manage the disorder.
AB - Mood disorders can be considered among the most common and debilitating mental disorders. Major depression, as an example of mood disorders, is known to severely reduce the quality of life as well as psychosocial functioning of those affected. Its impact on the burden of disease worldwide has been enormous, with the World Health Organisation projecting depression to be the leading cause of mental illness by 2030. Despite several studies on the subject, little has been done to contextualise the condition in Africa, coupled with the fact that there is still much to be understood on the subject. This review attempts to shed more light on the prevalence of depression in Sub-Saharan Africa (SSA), its pathophysiology, risk factors, diagnosis and the experimental models available to study depression within the sub-region. It also evaluates the contribution of the sub-region to the global research output of depression as well as bottlenecks associated with full exploitation of the sub region's resources to manage the disorder.
KW - Antidepressants
KW - Major depressive disorder
KW - Medicinal plants
KW - Sub-Saharan Africa
UR - http://www.scopus.com/inward/record.url?scp=85134498044&partnerID=8YFLogxK
U2 - 10.1016/j.ibneur.2022.03.005
DO - 10.1016/j.ibneur.2022.03.005
M3 - Article
AN - SCOPUS:85134498044
SN - 2667-2421
VL - 12
SP - 309
EP - 322
JO - IBRO Neuroscience Reports
JF - IBRO Neuroscience Reports
ER -
