TY - JOUR
T1 - Constituents of the Roots of Dichapetalum pallidum and Their Anti-Proliferative Activity
AU - Osei-Safo, Dorcas
AU - Dziwornu, Godwin Akpeko
AU - Appiah-Opong, Regina
AU - Chama, Mary Anti
AU - Tuffour, Isaac
AU - Waibel, Reiner
AU - Amewu, Richard
AU - Addae-Mensah, Ivan
AU - Newman, David J.
N1 - Publisher Copyright:
© 2017 by the author. Licensee MDPI, Basel, Switzerland.
PY - 2017/4
Y1 - 2017/4
N2 - As part of our search for bioactive compounds from the Dichapetalaceae, repeated chromatographic purification of the roots of a hitherto unexamined species, Dichapetalum pallidum, led to the isolation of the newly occurring 7-hydroxydichapetalin P (1) and the known dichapetalins A (2) and X (3). Also isolated were the known compounds friedelin-2,3-lactone (4), friedelan-3-one (6), friedelan-3β-ol (7) and pomolic (8), as well as the dipeptide aurantiamide acetate (5). The compounds were characterized by direct interpretation of their IR, 1D NMR and 2D NMR spectral data and by comparison of their physico-chemical data, including their chromatographic profiles, with the literature and authentic samples in our compound library for the genus Dichapetalum. The compounds were assayed for their anti-proliferative activities against the human T-lymphocytic leukemia (Jurkat), acute promyelocytic leukemia (HL-60) and T-lymphoblast-like leukemia (CEM) cell lines. Overall, dichapetalin X showed the strongest (3.14 μM) and broadest cytotoxic activities against all the leukemic cell lines tested, exhibiting even stronger activities than the standard compound, curcumin.
AB - As part of our search for bioactive compounds from the Dichapetalaceae, repeated chromatographic purification of the roots of a hitherto unexamined species, Dichapetalum pallidum, led to the isolation of the newly occurring 7-hydroxydichapetalin P (1) and the known dichapetalins A (2) and X (3). Also isolated were the known compounds friedelin-2,3-lactone (4), friedelan-3-one (6), friedelan-3β-ol (7) and pomolic (8), as well as the dipeptide aurantiamide acetate (5). The compounds were characterized by direct interpretation of their IR, 1D NMR and 2D NMR spectral data and by comparison of their physico-chemical data, including their chromatographic profiles, with the literature and authentic samples in our compound library for the genus Dichapetalum. The compounds were assayed for their anti-proliferative activities against the human T-lymphocytic leukemia (Jurkat), acute promyelocytic leukemia (HL-60) and T-lymphoblast-like leukemia (CEM) cell lines. Overall, dichapetalin X showed the strongest (3.14 μM) and broadest cytotoxic activities against all the leukemic cell lines tested, exhibiting even stronger activities than the standard compound, curcumin.
UR - http://www.scopus.com/inward/record.url?scp=85016307487&partnerID=8YFLogxK
U2 - 10.3390/molecules22040532
DO - 10.3390/molecules22040532
M3 - Article
C2 - 28346380
AN - SCOPUS:85016307487
SN - 1420-3049
VL - 22
JO - Molecules
JF - Molecules
IS - 4
M1 - 532
ER -