TY - JOUR
T1 - Clinical characteristics of males with systemic lupus erythematosus (SLE) in an inception cohort of patients in Ghana
AU - Dey, Dzifa
AU - Ofori, Emmanuel
AU - Hutton-Mensah, Kojo A.
AU - Akutek, Martin Luther King
AU - Okine, Rafiq
AU - Amoaba, Issifu
AU - Agyemang-Duah, Kwaku
AU - Kwarko, Harriet
N1 - Publisher Copyright:
© The Author(s). This is an Open Access article under the CC BY license.
PY - 2019
Y1 - 2019
N2 - Background: Systemic Lupus Erythematosus (SLE) is said to be rare in Sub-Saharan Africa and even rarer in males worldwide. SLE is mostly considered a disease of women, though men may also be affected, and this may lead to a delay in diagnosis in men. The result is a greater burden of inflammation and subsequent organ damage over time. Method: Data from the medical records of 13 male patients diagnosed with SLE at the Rheumatology Clinic of Korle-Bu Teaching Hospital between January 2014 and January 2017 was retrospectively analyzed. Results: A total of 13 male patients out of a total of 134 SLE patients were included in our analysis. The mean age was 30.62 ± SD 8.47 years (range of 17 to 46 years). All of them (100%) presented with constitutional features. The most common ACR criteria observed was 61.5 % rash, 54.5 % oral ulcers, 92.3% arthritis, 61.5 % serositis and 38.5% renal involvement, 46.2 % CNS involvement. Looking at their serological profile, 91.7 % had a positive antinuclear antibody (ANA). 33.3 % had positive anti-dsDNA and 58.3 % extractable nuclear antigens. The mean duration from onset of symptoms to diagnosis was 21.31 months. Five patients were diagnosed with lupus nephritis, all at the time of diagnosis. There were no mortalities. Conclusion: Male SLE patients in Ghana are comparable to other populations, with arthritis and constitutional features being predominant early features and lupus nephritis being the main early indicator of organ damage. This should warrant aggressive management in male patients.
AB - Background: Systemic Lupus Erythematosus (SLE) is said to be rare in Sub-Saharan Africa and even rarer in males worldwide. SLE is mostly considered a disease of women, though men may also be affected, and this may lead to a delay in diagnosis in men. The result is a greater burden of inflammation and subsequent organ damage over time. Method: Data from the medical records of 13 male patients diagnosed with SLE at the Rheumatology Clinic of Korle-Bu Teaching Hospital between January 2014 and January 2017 was retrospectively analyzed. Results: A total of 13 male patients out of a total of 134 SLE patients were included in our analysis. The mean age was 30.62 ± SD 8.47 years (range of 17 to 46 years). All of them (100%) presented with constitutional features. The most common ACR criteria observed was 61.5 % rash, 54.5 % oral ulcers, 92.3% arthritis, 61.5 % serositis and 38.5% renal involvement, 46.2 % CNS involvement. Looking at their serological profile, 91.7 % had a positive antinuclear antibody (ANA). 33.3 % had positive anti-dsDNA and 58.3 % extractable nuclear antigens. The mean duration from onset of symptoms to diagnosis was 21.31 months. Five patients were diagnosed with lupus nephritis, all at the time of diagnosis. There were no mortalities. Conclusion: Male SLE patients in Ghana are comparable to other populations, with arthritis and constitutional features being predominant early features and lupus nephritis being the main early indicator of organ damage. This should warrant aggressive management in male patients.
KW - Male
KW - Nephritis
KW - Sub-Saharan Africa
KW - Systemic lupus erythematosus
UR - http://www.scopus.com/inward/record.url?scp=85067312991&partnerID=8YFLogxK
U2 - 10.4314/gmj.v53i1.1
DO - 10.4314/gmj.v53i1.1
M3 - Article
C2 - 31138937
AN - SCOPUS:85067312991
SN - 0016-9560
VL - 53
SP - 2
EP - 7
JO - Ghana Medical Journal
JF - Ghana Medical Journal
IS - 1
ER -