Abstract
Gene expression can be down-regulated, up-regulated or corrected by delivering specific nucleic acids to targeted tissues. Regulation of gene expression can be applied in the treatment of diseases (gene therapy). RNA interference (RNAi) is a phenomenon of sequence-specific gene silencing. Since the discovery of RNAi, significant progress has been made in terms of its application, particularly with the use of small interfering ribonucleic acid (siRNA). siRNA holds promise as a therapy, although there are a few challenges limiting its extensive clinical application. To maximize efficacy and reduce side effects, scientists have developed different delivery systems for siRNA that would aid its clinical application. These delivery systems can target any cancer-related genes. siRNA can decrease tumor cell proliferation, angiogenesis, tumor metastasis or drug resistance. In addition, siRNA therapy has proven effective in the treatment of eye diseases, liver diseases and respiratory diseases.
Original language | English |
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Title of host publication | Gene Delivery Systems |
Subtitle of host publication | Development and Applications |
Publisher | CRC Press |
Pages | 65-76 |
Number of pages | 12 |
ISBN (Electronic) | 9781000580297 |
ISBN (Print) | 9781032025506 |
DOIs | |
Publication status | Published - 1 Jan 2022 |