Clinical Applications of siRNA

Seth Kwabena Amponsah, Ismaila Adams, Kwasi Agyei Bugyei

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Gene expression can be down-regulated, up-regulated or corrected by delivering specific nucleic acids to targeted tissues. Regulation of gene expression can be applied in the treatment of diseases (gene therapy). RNA interference (RNAi) is a phenomenon of sequence-specific gene silencing. Since the discovery of RNAi, significant progress has been made in terms of its application, particularly with the use of small interfering ribonucleic acid (siRNA). siRNA holds promise as a therapy, although there are a few challenges limiting its extensive clinical application. To maximize efficacy and reduce side effects, scientists have developed different delivery systems for siRNA that would aid its clinical application. These delivery systems can target any cancer-related genes. siRNA can decrease tumor cell proliferation, angiogenesis, tumor metastasis or drug resistance. In addition, siRNA therapy has proven effective in the treatment of eye diseases, liver diseases and respiratory diseases.

Original languageEnglish
Title of host publicationGene Delivery Systems
Subtitle of host publicationDevelopment and Applications
PublisherCRC Press
Pages65-76
Number of pages12
ISBN (Electronic)9781000580297
ISBN (Print)9781032025506
DOIs
Publication statusPublished - 1 Jan 2022

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