Circulating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africa

the Ghana Breast Health Study Team

doi:10.1038/s41698-021-00219-7

Circulating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africa

the Ghana Breast Health Study Team

Kwame Nkrumah University of Science and Technology
Icahn School of Medicine at Mount Sinai
University of Washington
Fred Hutchinson Cancer Research Center
National Institutes of Health
Korle Bu Teaching Hospital
Komfo Anokye Teaching Hospital
Research Institute of the McGill University Health Centre
University of Ghana
University of Calgary
Ohio State University
Ontario Institute for Cancer Research
Edinburgh Cancer Research Centre
University of Toronto Faculty of Medicine
Columbia University Medical Center
Cancer Research UK
McGill University AIDS Centre
McGill University
Loma Linda University Health
Peace and Love Hospital
Kumasi Centre for Collaborative Research in Tropical Medicine (KCCR)
University of Edinburgh
Ghana Education Service
Komfo Anoyke Teaching Hospital
New York-Presbyterian/Weill Cornell Medical Center
Westat

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Circulating tumor DNA (ctDNA) sequencing studies could provide novel insights into the molecular pathology of cancer in sub-Saharan Africa. In 15 patient plasma samples collected at the time of diagnosis as part of the Ghana Breast Health Study and unselected for tumor grade and subtype, ctDNA was detected in a majority of patients based on whole- genome sequencing at high (30×) and low (0.1×) depths. Breast cancer driver copy number alterations were observed in the majority of patients.

Original language	English
Article number	83
Journal	npj Precision Oncology
Volume	5
Issue number	1
DOIs	https://doi.org/10.1038/s41698-021-00219-7
Publication status	Published - Dec 2021
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1038/s41698-021-00219-7

Cite this

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title = "Circulating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africa",

abstract = "Circulating tumor DNA (ctDNA) sequencing studies could provide novel insights into the molecular pathology of cancer in sub-Saharan Africa. In 15 patient plasma samples collected at the time of diagnosis as part of the Ghana Breast Health Study and unselected for tumor grade and subtype, ctDNA was detected in a majority of patients based on whole- genome sequencing at high (30×) and low (0.1×) depths. Breast cancer driver copy number alterations were observed in the majority of patients.",

author = "\{the Ghana Breast Health Study Team\} and Ahuno, \{Samuel Terkper\} and Doebley, \{Anna Lisa\} and Ahearn, \{Thomas U.\} and Joel Yarney and Nicholas Titiloye and Nancy Hamel and Ernest Adjei and Clegg-Lamptey, \{Joe Nat\} and Lawrence Edusei and Baffour Awuah and Xiaoyu Song and Verna Vanderpuye and Mustapha Abubakar and Maire Duggan and Stover, \{Daniel G.\} and Kofi Nyarko and Bartlett, \{John M.S.\} and Francis Aitpillah and Daniel Ansong and Gardner, \{Kevin L.\} and Boateng, \{Felix Andy\} and Bowcock, \{Anne M.\} and Carlos Caldas and Foulkes, \{William D.\} and Seth Wiafe and Beatrice Wiafe-Addai and Montserrat Garcia-Closas and Alexander Kwarteng and Gavin Ha and Figueroa, \{Jonine D.\} and Paz Polak and Robertson Adjei and Lucy Afriyie and Anthony Adjei and Florence Dedey and Victoria Okyne and Oti, \{Naomi Ohene\} and Evelyn Tay and Adu-Aryee and Angela Kenu and Obed Ekpedzor and Marion Alcpaloo and Isaac Boakye and Bernard Arhin and Emmanuel Assimah and Samuel Ka-Chungu and Joseph Oppong and Ernest Osei-Bonsu and Margaret Frempong and Abaidoo, \{Emma Brew\}",

note = "Publisher Copyright: {\textcopyright} 2021, The Author(s).",

year = "2021",

month = dec,

doi = "10.1038/s41698-021-00219-7",

language = "English",

volume = "5",

journal = "npj Precision Oncology",

issn = "2397-768X",

publisher = "Nature Research",

number = "1",

}

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T1 - Circulating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africa

AU - the Ghana Breast Health Study Team

AU - Ahuno, Samuel Terkper

AU - Doebley, Anna Lisa

AU - Ahearn, Thomas U.

AU - Yarney, Joel

AU - Titiloye, Nicholas

AU - Hamel, Nancy

AU - Adjei, Ernest

AU - Clegg-Lamptey, Joe Nat

AU - Edusei, Lawrence

AU - Awuah, Baffour

AU - Song, Xiaoyu

AU - Vanderpuye, Verna

AU - Abubakar, Mustapha

AU - Duggan, Maire

AU - Stover, Daniel G.

AU - Nyarko, Kofi

AU - Bartlett, John M.S.

AU - Aitpillah, Francis

AU - Ansong, Daniel

AU - Gardner, Kevin L.

AU - Boateng, Felix Andy

AU - Bowcock, Anne M.

AU - Caldas, Carlos

AU - Foulkes, William D.

AU - Wiafe, Seth

AU - Wiafe-Addai, Beatrice

AU - Garcia-Closas, Montserrat

AU - Kwarteng, Alexander

AU - Ha, Gavin

AU - Figueroa, Jonine D.

AU - Polak, Paz

AU - Adjei, Robertson

AU - Afriyie, Lucy

AU - Adjei, Anthony

AU - Dedey, Florence

AU - Okyne, Victoria

AU - Oti, Naomi Ohene

AU - Tay, Evelyn

AU - Adu-Aryee,

AU - Kenu, Angela

AU - Ekpedzor, Obed

AU - Alcpaloo, Marion

AU - Boakye, Isaac

AU - Arhin, Bernard

AU - Assimah, Emmanuel

AU - Ka-Chungu, Samuel

AU - Oppong, Joseph

AU - Osei-Bonsu, Ernest

AU - Frempong, Margaret

AU - Abaidoo, Emma Brew

PY - 2021/12

Y1 - 2021/12

N2 - Circulating tumor DNA (ctDNA) sequencing studies could provide novel insights into the molecular pathology of cancer in sub-Saharan Africa. In 15 patient plasma samples collected at the time of diagnosis as part of the Ghana Breast Health Study and unselected for tumor grade and subtype, ctDNA was detected in a majority of patients based on whole- genome sequencing at high (30×) and low (0.1×) depths. Breast cancer driver copy number alterations were observed in the majority of patients.

AB - Circulating tumor DNA (ctDNA) sequencing studies could provide novel insights into the molecular pathology of cancer in sub-Saharan Africa. In 15 patient plasma samples collected at the time of diagnosis as part of the Ghana Breast Health Study and unselected for tumor grade and subtype, ctDNA was detected in a majority of patients based on whole- genome sequencing at high (30×) and low (0.1×) depths. Breast cancer driver copy number alterations were observed in the majority of patients.

UR - https://www.scopus.com/pages/publications/85116954878

U2 - 10.1038/s41698-021-00219-7

DO - 10.1038/s41698-021-00219-7

M3 - Article

AN - SCOPUS:85116954878

SN - 2397-768X

VL - 5

JO - npj Precision Oncology

JF - npj Precision Oncology

IS - 1

M1 - 83

ER -

Circulating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africa

Abstract

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