Characterization of Sesquiterpene Dimers from the Flowers of Inula japonica and the Structural Revisions of Related Compounds

Zheng Niu, Chun Yan Chen, Yan Zhou, Guan Ke Liu, Bing Yang Zhang, Mahmood Brobbey Oppong, De Qin Zhang, Tie Yao, Feng Qiu

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Sesquiterpene dimers are mainly found in the Asteraceae family. However, conflicting reports on the structures of these compounds can be found in the literature. Herein, we describe ten sesquiterpene dimers isolated from the flowers of Inula japonica, including configurational revisions of japonicone H (1-1), japonicone D (2-1), inulanolide A (4-1), japonicone X (5-1), and inulanolide F (5-2) to compounds 1, 2, 4, and 5, respectively. Five new related metabolites (3 and 6-9) are also described. Application of GIAO NMR/DP4+ analyses and ECD/OR calculations enabled us to revise the absolute configurations of an additional 13 sesquiterpene dimers isolated from plants of the genus Inula. Compounds 1, 2, 4, and 6 exhibited inhibition of nitric oxide production in lipopolysaccharide activated RAW264.7 macrophages with IC50 values of 4.07-10.00 μM.

Original languageEnglish
Pages (from-to)1754-1762
Number of pages9
JournalJournal of Natural Products
Volume87
Issue number7
DOIs
Publication statusPublished - 26 Jul 2024

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