Butremycin, the 3-hydroxyl derivative of ikarugamycin and a protonated aromatic tautomer of 5′-methylthioinosine from a Ghanaian Micromonospora sp. K310

Kwaku Kyeremeh, Kojo Sekyi Acquah, Anil Sazak, Wael Houssen, Jioji Tabudravu, Hai Deng, Marcel Jaspars

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42 Citations (Scopus)

Abstract

A new actinomycete strain Micromonospora sp. K310 was isolated from Ghanaian mangrove river sediment. Spectroscopy-guided fractionation led to the isolation of two new compounds from the fermentation culture. One of the compounds is butremycin ( 2) which is the (3-hydroxyl) derivative of the known Streptomyces metabolite ikarugamycin (1) and the other compound is a protonated aromatic tautomer of 5′-methylthioinosine (MTI) (3). Both new compounds were characterized by 1D, 2D NMR and MS data. Butremycin (2) displayed weak antibacterial activity against Gram-positive S. aureus ATCC 25923, the Gram-negative E. coli ATCC 25922 and a panel of clinical isolates of methicillin-resistant S. aureus (MRSA) strains while 3 did not show any antibacterial activity against these microbes.

Original languageEnglish
Pages (from-to)999-1012
Number of pages14
JournalMarine Drugs
Volume12
Issue number2
DOIs
Publication statusPublished - Feb 2014

Keywords

  • Macrolactam
  • Mangroves
  • Micromonospora
  • Tautomer
  • Tetramic acid

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