Abstract
A new actinomycete strain Micromonospora sp. K310 was isolated from Ghanaian mangrove river sediment. Spectroscopy-guided fractionation led to the isolation of two new compounds from the fermentation culture. One of the compounds is butremycin ( 2) which is the (3-hydroxyl) derivative of the known Streptomyces metabolite ikarugamycin (1) and the other compound is a protonated aromatic tautomer of 5′-methylthioinosine (MTI) (3). Both new compounds were characterized by 1D, 2D NMR and MS data. Butremycin (2) displayed weak antibacterial activity against Gram-positive S. aureus ATCC 25923, the Gram-negative E. coli ATCC 25922 and a panel of clinical isolates of methicillin-resistant S. aureus (MRSA) strains while 3 did not show any antibacterial activity against these microbes.
Original language | English |
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Pages (from-to) | 999-1012 |
Number of pages | 14 |
Journal | Marine Drugs |
Volume | 12 |
Issue number | 2 |
DOIs | |
Publication status | Published - Feb 2014 |
Keywords
- Macrolactam
- Mangroves
- Micromonospora
- Tautomer
- Tetramic acid