TY - JOUR
T1 - Burden and epidemiology of rotavirus diarrhea in selected african countries
T2 - Preliminary results from the african rotavirus surveillance network
AU - Mwenda, Jason M.
AU - Ntoto, Kinkela Mina
AU - Abebe, Almaz
AU - Enweronu-Laryea, Christabel
AU - Amina, Ismail
AU - Mchomvu, Jackson
AU - Kisakye, Annet
AU - Mpabalwani, Evans M.
AU - Pazvakavambwa, Isoro
AU - Armah, George E.
AU - Seheri, L. M.
AU - Kiulia, Nicholas M.
AU - Page, N.
AU - Widdowson, Marc Alain
AU - Steele, A. Duncan
PY - 2010/9/1
Y1 - 2010/9/1
N2 - Severe rotavirus diarrhea in children <5 years of age is a major public health problem; however, limited regional and country specific data on rotavirus disease burden are available from sub-Saharan Africa. In June 2006, the World Health Organization Regional Office for Africa initiated rotavirus surveillance in selected African countries.With use of standardized methodology developed by theWorld Health Organization, children <5 years of age who were hospitalized with severe diarrhea were enrolled, and stool specimens were collected for detection of rotavirus strains with use of a commercial enzyme immunoassay. Rotavirus strains were further characterized for G and P types with use of a reverse-transcriptase polymerase chain reaction. From June 2006 through December 2008, rotavirus surveillance was established at 14 sites in 11 African countries. Of 5461 stool samples collected from children enrolled in 8 countries with 1 or 2 complete years of data, 2200 (40%) were positive for rotavirus. Ninety percent of all rotavirus hospitalizations occurred among children aged 3-12 months. Predominant types included G1P[8] (21%), G2P[4] (7%), and P [8] (29%); however, unusual types were also detected, including G8P[6] (5%), G8P[8] (1%), G12P[6] (1%), and G12P[6] (1%). A high percentage of mixed rotavirus infections was also detected. These preliminary results indicate that rotavirus is a major cause of severe diarrheal disease in African children.
AB - Severe rotavirus diarrhea in children <5 years of age is a major public health problem; however, limited regional and country specific data on rotavirus disease burden are available from sub-Saharan Africa. In June 2006, the World Health Organization Regional Office for Africa initiated rotavirus surveillance in selected African countries.With use of standardized methodology developed by theWorld Health Organization, children <5 years of age who were hospitalized with severe diarrhea were enrolled, and stool specimens were collected for detection of rotavirus strains with use of a commercial enzyme immunoassay. Rotavirus strains were further characterized for G and P types with use of a reverse-transcriptase polymerase chain reaction. From June 2006 through December 2008, rotavirus surveillance was established at 14 sites in 11 African countries. Of 5461 stool samples collected from children enrolled in 8 countries with 1 or 2 complete years of data, 2200 (40%) were positive for rotavirus. Ninety percent of all rotavirus hospitalizations occurred among children aged 3-12 months. Predominant types included G1P[8] (21%), G2P[4] (7%), and P [8] (29%); however, unusual types were also detected, including G8P[6] (5%), G8P[8] (1%), G12P[6] (1%), and G12P[6] (1%). A high percentage of mixed rotavirus infections was also detected. These preliminary results indicate that rotavirus is a major cause of severe diarrheal disease in African children.
UR - http://www.scopus.com/inward/record.url?scp=77955698171&partnerID=8YFLogxK
U2 - 10.1086/653557
DO - 10.1086/653557
M3 - Article
C2 - 20684718
AN - SCOPUS:77955698171
SN - 0022-1899
VL - 202
SP - S5-S11
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - SUPPL. 1
ER -