Brief communication: coagulation profiles of HIV positive patients on antiretroviral therapy (ART) at the Mampong Municipal Hospital, Ashanti-Region, Ghana: a case control study

Freddie Boateng Opoku; Akua Koaso Yalley; Nicholas Israel Nii-Trebi; Ekoutiame Ahlin; Abena Asefuaba Yalley; Ransford Kyeremeh

doi:10.1186/s12981-024-00665-w

Brief communication: coagulation profiles of HIV positive patients on antiretroviral therapy (ART) at the Mampong Municipal Hospital, Ashanti-Region, Ghana: a case control study

Freddie Boateng Opoku
, Akua Koaso Yalley
, Nicholas Israel Nii-Trebi
, Ekoutiame Ahlin
, Abena Asefuaba Yalley
, Ransford Kyeremeh

Department of Medical Laboratory Sciences

University of Ghana
Free University of Berlin
Center for Research and Opinion Polls (CROP)
University of Konstanz

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

This study aimed to ascertain how the current two ART regimens used in Ghana affected HIV patients’ coagulation profiles. A case-control study was conducted on 102 HIV positive patients at the Mampong Municipal Hospital. Coagulation parameters measured showed APTT was normal in majority of ART-experienced participants but prolonged in majority of ART-naïve participants. The mean platelet count was significantly higher in ART-experienced participants. No significant differences were found between the coagulation profiles of ART-experienced patients on two different drug regimens. In conclusion, current ART can enhance the coagulation profiles in HIV-infected patients, by improving platelet count and APTT.

Original language	English
Article number	72
Journal	AIDS Research and Therapy
Volume	21
Issue number	1
DOIs	https://doi.org/10.1186/s12981-024-00665-w
Publication status	Published - Dec 2024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Activated partial thromboplastin time
Antiretroviral therapy
Coagulation profile
Human immunodeficiency virus
International normalized ratio
Platelet count

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10.1186/s12981-024-00665-w

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title = "Brief communication: coagulation profiles of HIV positive patients on antiretroviral therapy (ART) at the Mampong Municipal Hospital, Ashanti-Region, Ghana: a case control study",

abstract = "This study aimed to ascertain how the current two ART regimens used in Ghana affected HIV patients{\textquoteright} coagulation profiles. A case-control study was conducted on 102 HIV positive patients at the Mampong Municipal Hospital. Coagulation parameters measured showed APTT was normal in majority of ART-experienced participants but prolonged in majority of ART-na{\"i}ve participants. The mean platelet count was significantly higher in ART-experienced participants. No significant differences were found between the coagulation profiles of ART-experienced patients on two different drug regimens. In conclusion, current ART can enhance the coagulation profiles in HIV-infected patients, by improving platelet count and APTT.",

keywords = "Activated partial thromboplastin time, Antiretroviral therapy, Coagulation profile, Human immunodeficiency virus, International normalized ratio, Platelet count",

author = "Opoku, \{Freddie Boateng\} and Yalley, \{Akua Koaso\} and Nii-Trebi, \{Nicholas Israel\} and Ekoutiame Ahlin and Yalley, \{Abena Asefuaba\} and Ransford Kyeremeh",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",

year = "2024",

month = dec,

doi = "10.1186/s12981-024-00665-w",

language = "English",

volume = "21",

journal = "AIDS Research and Therapy",

issn = "1742-6405",

publisher = "BioMed Central Ltd.",

number = "1",

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Brief communication: coagulation profiles of HIV positive patients on antiretroviral therapy (ART) at the Mampong Municipal Hospital, Ashanti-Region, Ghana: a case control study. / Opoku, Freddie Boateng; Yalley, Akua Koaso; Nii-Trebi, Nicholas Israel et al.
In: AIDS Research and Therapy, Vol. 21, No. 1, 72, 12.2024.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Brief communication

T2 - coagulation profiles of HIV positive patients on antiretroviral therapy (ART) at the Mampong Municipal Hospital, Ashanti-Region, Ghana: a case control study

AU - Opoku, Freddie Boateng

AU - Yalley, Akua Koaso

AU - Nii-Trebi, Nicholas Israel

AU - Ahlin, Ekoutiame

AU - Yalley, Abena Asefuaba

AU - Kyeremeh, Ransford

N1 - Publisher Copyright: © The Author(s) 2024.

PY - 2024/12

Y1 - 2024/12

N2 - This study aimed to ascertain how the current two ART regimens used in Ghana affected HIV patients’ coagulation profiles. A case-control study was conducted on 102 HIV positive patients at the Mampong Municipal Hospital. Coagulation parameters measured showed APTT was normal in majority of ART-experienced participants but prolonged in majority of ART-naïve participants. The mean platelet count was significantly higher in ART-experienced participants. No significant differences were found between the coagulation profiles of ART-experienced patients on two different drug regimens. In conclusion, current ART can enhance the coagulation profiles in HIV-infected patients, by improving platelet count and APTT.

AB - This study aimed to ascertain how the current two ART regimens used in Ghana affected HIV patients’ coagulation profiles. A case-control study was conducted on 102 HIV positive patients at the Mampong Municipal Hospital. Coagulation parameters measured showed APTT was normal in majority of ART-experienced participants but prolonged in majority of ART-naïve participants. The mean platelet count was significantly higher in ART-experienced participants. No significant differences were found between the coagulation profiles of ART-experienced patients on two different drug regimens. In conclusion, current ART can enhance the coagulation profiles in HIV-infected patients, by improving platelet count and APTT.

KW - Activated partial thromboplastin time

KW - Antiretroviral therapy

KW - Coagulation profile

KW - Human immunodeficiency virus

KW - International normalized ratio

KW - Platelet count

UR - https://www.scopus.com/pages/publications/85207187639

U2 - 10.1186/s12981-024-00665-w

DO - 10.1186/s12981-024-00665-w

M3 - Article

C2 - 39438958

AN - SCOPUS:85207187639

SN - 1742-6405

VL - 21

JO - AIDS Research and Therapy

JF - AIDS Research and Therapy

IS - 1

M1 - 72

ER -

Brief communication: coagulation profiles of HIV positive patients on antiretroviral therapy (ART) at the Mampong Municipal Hospital, Ashanti-Region, Ghana: a case control study

Abstract

UN SDGs

Keywords

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