TY - JOUR
T1 - Brief communication
T2 - coagulation profiles of HIV positive patients on antiretroviral therapy (ART) at the Mampong Municipal Hospital, Ashanti-Region, Ghana: a case control study
AU - Opoku, Freddie Boateng
AU - Yalley, Akua Koaso
AU - Nii-Trebi, Nicholas Israel
AU - Ahlin, Ekoutiame
AU - Yalley, Abena Asefuaba
AU - Kyeremeh, Ransford
N1 - Publisher Copyright:
© 2024. The Author(s).
PY - 2024/10/22
Y1 - 2024/10/22
N2 - This study aimed to ascertain how the current two ART regimens used in Ghana affected HIV patients' coagulation profiles. A case-control study was conducted on 102 HIV positive patients at the Mampong Municipal Hospital. Coagulation parameters measured showed APTT was normal in majority of ART-experienced participants but prolonged in majority of ART-naïve participants. The mean platelet count was significantly higher in ART-experienced participants. No significant differences were found between the coagulation profiles of ART-experienced patients on two different drug regimens. In conclusion, current ART can enhance the coagulation profiles in HIV-infected patients, by improving platelet count and APTT.
AB - This study aimed to ascertain how the current two ART regimens used in Ghana affected HIV patients' coagulation profiles. A case-control study was conducted on 102 HIV positive patients at the Mampong Municipal Hospital. Coagulation parameters measured showed APTT was normal in majority of ART-experienced participants but prolonged in majority of ART-naïve participants. The mean platelet count was significantly higher in ART-experienced participants. No significant differences were found between the coagulation profiles of ART-experienced patients on two different drug regimens. In conclusion, current ART can enhance the coagulation profiles in HIV-infected patients, by improving platelet count and APTT.
KW - Activated partial thromboplastin time
KW - Antiretroviral therapy
KW - Coagulation profile
KW - Human immunodeficiency virus
KW - International normalized ratio
KW - Platelet count
UR - http://www.scopus.com/inward/record.url?scp=85207187639&partnerID=8YFLogxK
U2 - 10.1186/s12981-024-00665-w
DO - 10.1186/s12981-024-00665-w
M3 - Article
C2 - 39438958
AN - SCOPUS:85207187639
SN - 1742-6405
VL - 21
SP - 72
JO - AIDS Research and Therapy
JF - AIDS Research and Therapy
IS - 1
ER -