Bone cancer: Current status in preclinical research

The spread of cancer to the human bone, known as metastasis, frequently results in substantial morbidity and mortality. The primary cause of most cancer-related deaths is metastasis, as existing treatments are typically ineffective in treating cancer that has spread to other parts of the body. The early preclinical models of bone cancer entailed the introduction of cancer cells through systemic injection. Employing these models to evaluate metastasis is crucial for developing efficacious cancer diagnostics and therapies. The utilization of mice models in the research of this disease has proven to be highly advantageous for examining the mechanisms underlying carcinogenesis metastasis and evaluating potential therapeutic approaches. An optimal animal model should possess clinical relevance and reproducibility and accurately replicate human diseases. At present, there is no flawless model available. This chapter provides a concise overview of the mechanisms and models utilized in the preclinical domain.