Autophagy in immune defense against Mycobacterium tuberculosis

Isabelle Vergne; Sudha Singh; Esteban Roberts; George Kyei; Sharon Master; James Harris; Sergio De Haro; John Naylor; Alex Davis; Monica Delgado; Vojo Deretic

doi:10.4161/auto.2830

Autophagy in immune defense against Mycobacterium tuberculosis

Isabelle Vergne, Sudha Singh, Esteban Roberts, George Kyei, Sharon Master, James Harris, Sergio De Haro, John Naylor, Alex Davis, Monica Delgado, Vojo Deretic

Research output: Contribution to journal › Review article › peer-review

64 Citations (Scopus)

Abstract

Autophagy is a newly recognized innate and adaptive immunity defense against intracellular pathogens, in keeping with its role as a cytoplasmic maintenance pathway. Induction of autophagy by physiological, pharmacological or immunological means can eliminate intracellular Mycobacterium tuberculosis, providing one of the first examples of the immunological role of autophagy. Under normal circumstances, M. Tuberculosis survives in macrophages by inhibiting phagolysosome biogenesis. Induction of autophagy overcomes the mycobacterial phagosome maturation block, and delivers the tubercle bacilli to degradative compartments where they are eliminated.

Original language	English
Pages (from-to)	175-178
Number of pages	4
Journal	Autophagy
Volume	2
Issue number	3
DOIs	https://doi.org/10.4161/auto.2830
Publication status	Published - 2006
Externally published	Yes

Keywords

Autophagosome
GTpase
Interferon
Phagosome
Phosphatidylinositol

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4161/auto.2830

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title = "Autophagy in immune defense against Mycobacterium tuberculosis",

abstract = "Autophagy is a newly recognized innate and adaptive immunity defense against intracellular pathogens, in keeping with its role as a cytoplasmic maintenance pathway. Induction of autophagy by physiological, pharmacological or immunological means can eliminate intracellular Mycobacterium tuberculosis, providing one of the first examples of the immunological role of autophagy. Under normal circumstances, M. Tuberculosis survives in macrophages by inhibiting phagolysosome biogenesis. Induction of autophagy overcomes the mycobacterial phagosome maturation block, and delivers the tubercle bacilli to degradative compartments where they are eliminated.",

keywords = "Autophagosome, GTpase, Interferon, Phagosome, Phosphatidylinositol",

author = "Isabelle Vergne and Sudha Singh and Esteban Roberts and George Kyei and Sharon Master and James Harris and {De Haro}, Sergio and John Naylor and Alex Davis and Monica Delgado and Vojo Deretic",

year = "2006",

doi = "10.4161/auto.2830",

language = "English",

volume = "2",

pages = "175--178",

journal = "Autophagy",

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publisher = "Taylor and Francis Ltd.",

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TY - JOUR

T1 - Autophagy in immune defense against Mycobacterium tuberculosis

AU - Vergne, Isabelle

AU - Singh, Sudha

AU - Roberts, Esteban

AU - Kyei, George

AU - Master, Sharon

AU - Harris, James

AU - De Haro, Sergio

AU - Naylor, John

AU - Davis, Alex

AU - Delgado, Monica

AU - Deretic, Vojo

PY - 2006

Y1 - 2006

N2 - Autophagy is a newly recognized innate and adaptive immunity defense against intracellular pathogens, in keeping with its role as a cytoplasmic maintenance pathway. Induction of autophagy by physiological, pharmacological or immunological means can eliminate intracellular Mycobacterium tuberculosis, providing one of the first examples of the immunological role of autophagy. Under normal circumstances, M. Tuberculosis survives in macrophages by inhibiting phagolysosome biogenesis. Induction of autophagy overcomes the mycobacterial phagosome maturation block, and delivers the tubercle bacilli to degradative compartments where they are eliminated.

AB - Autophagy is a newly recognized innate and adaptive immunity defense against intracellular pathogens, in keeping with its role as a cytoplasmic maintenance pathway. Induction of autophagy by physiological, pharmacological or immunological means can eliminate intracellular Mycobacterium tuberculosis, providing one of the first examples of the immunological role of autophagy. Under normal circumstances, M. Tuberculosis survives in macrophages by inhibiting phagolysosome biogenesis. Induction of autophagy overcomes the mycobacterial phagosome maturation block, and delivers the tubercle bacilli to degradative compartments where they are eliminated.

KW - Autophagosome

KW - GTpase

KW - Interferon

KW - Phagosome

KW - Phosphatidylinositol

UR - http://www.scopus.com/inward/record.url?scp=33745855871&partnerID=8YFLogxK

U2 - 10.4161/auto.2830

DO - 10.4161/auto.2830

M3 - Review article

C2 - 16874111

AN - SCOPUS:33745855871

SN - 1554-8627

VL - 2

SP - 175

EP - 178

JO - Autophagy

JF - Autophagy

IS - 3

ER -

Autophagy in immune defense against Mycobacterium tuberculosis

Abstract

Keywords

UN SDGs

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