TY - JOUR
T1 - Autophagy as an immune effector against tuberculosis
AU - Bradfute, Steven B.
AU - Castillo, Eliseo F.
AU - Arko-Mensah, John
AU - Chauhan, Santosh
AU - Jiang, Shanya
AU - Mandell, Michael
AU - Deretic, Vojo
PY - 2013/6
Y1 - 2013/6
N2 - The now well-accepted innate immunity paradigm that autophagy acts as a cell-autonomous defense against intracellular bacteria has its key origins in studies with Mycobacterium tuberculosis, an important human pathogen and a model microorganism infecting macrophages. A number of different factors have been identified that play into the anti-mycobacterial functions of autophagy, and recent in vivo studies in the mouse model of tuberculosis have uncovered additional anti-inflammatory and tissue-sparing functions of autophagy. Complementing these observations, genome wide association studies indicate a considerable overlap between autophagy, human susceptibility to mycobacterial infections and predisposition loci for inflammatory bowel disease. Finally, recent studies show that autophagy is an important regulator and effector of IL-1 responses, and that autophagy intersects with type I interferon pathology-modulating responses.
AB - The now well-accepted innate immunity paradigm that autophagy acts as a cell-autonomous defense against intracellular bacteria has its key origins in studies with Mycobacterium tuberculosis, an important human pathogen and a model microorganism infecting macrophages. A number of different factors have been identified that play into the anti-mycobacterial functions of autophagy, and recent in vivo studies in the mouse model of tuberculosis have uncovered additional anti-inflammatory and tissue-sparing functions of autophagy. Complementing these observations, genome wide association studies indicate a considerable overlap between autophagy, human susceptibility to mycobacterial infections and predisposition loci for inflammatory bowel disease. Finally, recent studies show that autophagy is an important regulator and effector of IL-1 responses, and that autophagy intersects with type I interferon pathology-modulating responses.
UR - http://www.scopus.com/inward/record.url?scp=84881547839&partnerID=8YFLogxK
U2 - 10.1016/j.mib.2013.05.003
DO - 10.1016/j.mib.2013.05.003
M3 - Review article
AN - SCOPUS:84881547839
SN - 1369-5274
VL - 16
SP - 355
EP - 365
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
IS - 3
ER -