Abstract
Purpose: To evaluate associations between IFN-γ +874T/A and TNF-α-308G/A polymorphism with the development of Toxoplasma retinochoroiditis. Methods: By ARMS–PCR, a cross-sectional genetic study involving 30 patients with Toxoplasma retinochoroiditis and 87 controls was carried out. Results: IFN-γ +874: by comparing with the AA genotype, individuals with the TT genotype had a 3.4 odds ratio (OR); AT had a 1.6 OR; and the T allele had a higher OR (1.6), indicating a likely susceptibility of IFN-γ +874T to the infection, though the overall distribution was not significant (p = 0.259). For TNF-α-308G/A, individuals with both GA and AA genotypes had lower ORs when compared with the GG genotype, implying the A allele could confer protection against Toxoplasma ocular lesions. Conclusions: IFN-γ +874T allele may increase the risk of ocular lesions in Toxoplasma infection. The principle of natural selection seems to also play a role. The less common TNF-308A allelic form could be protective against the development of Toxoplasma ocular infection.
Original language | English |
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Pages (from-to) | 678-684 |
Number of pages | 7 |
Journal | Ocular Immunology and Inflammation |
Volume | 25 |
Issue number | 5 |
DOIs | |
Publication status | Published - 3 Sep 2017 |
Externally published | Yes |
Keywords
- Genes
- Ghana
- Toxoplasma
- interferon gamma
- retinochoroiditis
- tumor necrosis factor