Association of Immunoglobulin G3 Hinge Region Length Polymorphism With Cerebral Malaria in Ghanaian Children

Eric Kyei-Baafour, Kwadwo A. Kusi, Fareed K.N. Arthur, Tracy Sarkodie-Addo, Michael Theisen, Daniel Dodoo, Bright Adu

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Cerebral malaria (CM) may cause death or long-term neurological damage in children, and several host genetic risk factors have been reported. Malaria-specific immunoglobulin (Ig) G3 antibodies are crucial to human immune response against malaria. The hinge region of IgG3 exhibits length polymorphism (with long [L], medium [M], and short [S] alleles), which may influence its functionality. We studied IgG3 hinge region length polymorphisms in 136 Ghanaian children with malaria. Using logistic regression models, we found that children with the recessive MM allotype encoding medium IgG3 hinge region length had an increased risk of CM (adjusted odds ratio, 6.67 [95% confidence interval,1.30-34.32]; P=.004). This has implications for future epidemiological studies on CM.

Original languageEnglish
Pages (from-to)1786-1790
Number of pages5
JournalJournal of Infectious Diseases
Volume225
Issue number10
DOIs
Publication statusPublished - 15 May 2022
Externally publishedYes

Keywords

  • IGHG3 gene
  • IgG3 hinge region
  • Plasmodium falciparum
  • cerebral malaria
  • polymorphism

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