TY - JOUR
T1 - Association of Endothelial Protein C Receptor (EPCR) rs867186 Gene Polymorphism With Increased Levels of Soluble EPCR and High Risk of Severe Malaria and Fatality in Beninese Children
AU - Blankson, Samuel Odarkwei
AU - Dikroh, Liliane
AU - Tettey, Patrick
AU - Tornyigah, Bernard
AU - Adamou, Rafiou
AU - Moussiliou, Azizath
AU - Alao, Maroufou J.
AU - Amoussou, Annick
AU - Padounou, Caroline
AU - Milet, Jacqueline
AU - Mensah, Benedicta Ayiedu
AU - Aniweh, Yaw
AU - Ndam, Nicaise Tuikue
AU - Roussilhon, Christian
AU - Tahar, Rachida
N1 - Publisher Copyright:
© 2022 The Author(s).
PY - 2023/1/15
Y1 - 2023/1/15
N2 - The endothelial protein C receptor (EPCR)-rs867186 G allele has been linked to high plasma levels of soluble EPCR (sEPCR) and controversially associated with either susceptibility or resistance to severe and cerebral malaria. In this study, quantitative enzyme-linked immunosorbent assay and sequencing were used to assess sEPCR levels and EPCR-rs867186 polymorphism in blood samples from Beninese children with different clinical presentations of malaria. Our findings show that sEPCR levels were higher at hospital admission than during convalescence and that EPCR-rs867186 G allele was associated with increased sEPCR plasma levels, malaria severity, and mortality rate (P <. 001, P =. 03, and P =. 04, respectively), suggesting a role of sEPCR in the pathogenesis of severe malaria.
AB - The endothelial protein C receptor (EPCR)-rs867186 G allele has been linked to high plasma levels of soluble EPCR (sEPCR) and controversially associated with either susceptibility or resistance to severe and cerebral malaria. In this study, quantitative enzyme-linked immunosorbent assay and sequencing were used to assess sEPCR levels and EPCR-rs867186 polymorphism in blood samples from Beninese children with different clinical presentations of malaria. Our findings show that sEPCR levels were higher at hospital admission than during convalescence and that EPCR-rs867186 G allele was associated with increased sEPCR plasma levels, malaria severity, and mortality rate (P <. 001, P =. 03, and P =. 04, respectively), suggesting a role of sEPCR in the pathogenesis of severe malaria.
KW - EPCR
KW - cerebral malaria
KW - polymorphism
KW - rs867186
UR - http://www.scopus.com/inward/record.url?scp=85146193546&partnerID=8YFLogxK
U2 - 10.1093/infdis/jiac461
DO - 10.1093/infdis/jiac461
M3 - Article
C2 - 36416015
AN - SCOPUS:85146193546
SN - 0022-1899
VL - 227
SP - 179
EP - 182
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 2
ER -