TY - JOUR
T1 - Assessment of the Proportion of Recent HIV-1 Infections in Newly-Diagnosed Cases in Ghana
AU - Matsuoka, Saori
AU - Adusei-Poku, Mildred Asumamaa
AU - Abana, Christopher Zab Yen
AU - Duker, Ewurabena Oduma
AU - Bonney, Evelyn Yayra
AU - Ofori, Sampson Badu
AU - Parbie, Prince Kofi
AU - Okazaki, Midori
AU - Kawana-Tachikawa, Ai
AU - Ishikawa, Koichi
AU - Ampofo, William Kwabena
AU - Matano, Tetsuro
N1 - Publisher Copyright:
© 2022, National Institute of Health. All rights reserved.
PY - 2022
Y1 - 2022
N2 - Accurat e moni t ori ng of epi demi cs i s a key st rat egy for cont rol l i ng human immunodeficiency virus type-1 (HIV-1) infection. To delineate the characteristics of newly-diagnosed cases of HIV-1 infection, we assessed the proportion of recent HIV-1 infections using a recent infection-testing algorithm (RITA). In 2015, 248 cases were newly diagnosed with HIV infection at the Regional Hospital Koforidua, Ghana. Of these, 234 cases (94.4%) were infected with HIV-1 only, four (1.6%) were infected with HIV-2 only, and 10 (4.0%) were co-infected with HIV-1 and HIV-2. All HIV-1 single-seropositive samples were used in the HIV-1 LAg avidity assay for RITA. Our analysis revealed that 18 cases (7.7%) were recently infected, indicating that early diagnosis was not achieved in Ghana. This is the first report to assess the proportion of recent infections in Ghana using a biomarker approach. The accumulation of these data will contribute to the accurate estimation of HIV-1 incidence and prevalence in Ghana.
AB - Accurat e moni t ori ng of epi demi cs i s a key st rat egy for cont rol l i ng human immunodeficiency virus type-1 (HIV-1) infection. To delineate the characteristics of newly-diagnosed cases of HIV-1 infection, we assessed the proportion of recent HIV-1 infections using a recent infection-testing algorithm (RITA). In 2015, 248 cases were newly diagnosed with HIV infection at the Regional Hospital Koforidua, Ghana. Of these, 234 cases (94.4%) were infected with HIV-1 only, four (1.6%) were infected with HIV-2 only, and 10 (4.0%) were co-infected with HIV-1 and HIV-2. All HIV-1 single-seropositive samples were used in the HIV-1 LAg avidity assay for RITA. Our analysis revealed that 18 cases (7.7%) were recently infected, indicating that early diagnosis was not achieved in Ghana. This is the first report to assess the proportion of recent infections in Ghana using a biomarker approach. The accumulation of these data will contribute to the accurate estimation of HIV-1 incidence and prevalence in Ghana.
UR - https://www.scopus.com/pages/publications/85134606346
U2 - 10.7883/yoken.JJID.2021.573
DO - 10.7883/yoken.JJID.2021.573
M3 - Article
C2 - 34980705
AN - SCOPUS:85134606346
SN - 1344-6304
VL - 75
SP - 395
EP - 397
JO - Japanese Journal of Infectious Diseases
JF - Japanese Journal of Infectious Diseases
IS - 4
ER -
