Assessment of the Proportion of Recent HIV-1 Infections in Newly-Diagnosed Cases in Ghana

Saori Matsuoka, Mildred Asumamaa Adusei-Poku, Christopher Zab Yen Abana, Ewurabena Oduma Duker, Evelyn Yayra Bonney, Sampson Badu Ofori, Prince Kofi Parbie, Midori Okazaki, Ai Kawana-Tachikawa, Koichi Ishikawa, William Kwabena Ampofo, Tetsuro Matano

Research output: Contribution to journalArticlepeer-review

Abstract

Accurat e moni t ori ng of epi demi cs i s a key st rat egy for cont rol l i ng human immunodeficiency virus type-1 (HIV-1) infection. To delineate the characteristics of newly-diagnosed cases of HIV-1 infection, we assessed the proportion of recent HIV-1 infections using a recent infection-testing algorithm (RITA). In 2015, 248 cases were newly diagnosed with HIV infection at the Regional Hospital Koforidua, Ghana. Of these, 234 cases (94.4%) were infected with HIV-1 only, four (1.6%) were infected with HIV-2 only, and 10 (4.0%) were co-infected with HIV-1 and HIV-2. All HIV-1 single-seropositive samples were used in the HIV-1 LAg avidity assay for RITA. Our analysis revealed that 18 cases (7.7%) were recently infected, indicating that early diagnosis was not achieved in Ghana. This is the first report to assess the proportion of recent infections in Ghana using a biomarker approach. The accumulation of these data will contribute to the accurate estimation of HIV-1 incidence and prevalence in Ghana.

Original languageEnglish
Pages (from-to)395-397
Number of pages3
JournalJapanese Journal of Infectious Diseases
Volume75
Issue number4
DOIs
Publication statusPublished - 2022
Externally publishedYes

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