Assessment of the performance of haematological and non-invasive fibrotic indices for the monitoring of chronic HBV infection: a pilot study in a Ghanaian population

Eric N.Y. Nyarko, Christian Obirikorang, W. K.B.A. Owiredu, Evans Asamoah Adu, Emmanuel Acheampong

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Objective: Haematological and liver fibrotic markers could be appreciably utilized for effective monitoring of Chronic Hepatitis B viral (HBV) infection, thereby increasing patient’s treatment outcome. The objective of this study was to assess the applicability of complete blood count (CBC) and non-invasive liver-fibrotic indices as markers of prognostic outcome and monitoring in HBV infections. Results: Significant differences in levels of white cell and differentials counts, red blood cell count, hemoglobin indices, and platelet indices were observed between HBV-infected patients (cases) and uninfected persons (controls). Levels of haemoglobin (Hb), total white blood cells (tWBC), neutrophils, monocytes, platelets, and Platelet Distribution width (PDW) were significantly lower (p < 0.05) in the cases compared to the controls. Total and indirect bilirubin; De-Ritis ratio, Aspartate transaminase to platelet ratio index (APRI) and RDW-to-platelet ratio (RPR) were elevated in cases compared with controls (p-value < 0.05). In a multivariate adjusted model to test the significance of markers, Hemoglobin Index (beta coefficient = − 0.876, p-value < 0.001), NLR (beta coefficient = − 0.839, p-value < 0.001), MPV_10000 (beta coefficient = − 0.333, p-value < 0.001) and Albumin (beta coefficient = − 0.059, p-value = 0.014), were associated with HBV infection status. Receiver operative characteristics curve analysis showed Hemoglobin Index (AUC = 0.744) and MPV_10000 (AUC = 0.730) as better prognostic markers for HBV-infection.

Original languageEnglish
Article number312
JournalBMC Research Notes
Volume16
Issue number1
DOIs
Publication statusPublished - Dec 2023

Keywords

  • Biochemical
  • Chronic HBV status
  • Fibrotic indices
  • Ghanaians
  • HBV infection
  • Hematological

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