TY - JOUR
T1 - Artesunate plus amodiaquine combination therapy
T2 - Reviewing the evidence
AU - Adjei, George O.
AU - Kudzi, William
AU - Dodoo, Alexander
AU - Kurtzhals, Jorgen A.L.
PY - 2010/2
Y1 - 2010/2
N2 - The combination of artesunate plus amodiaquine (AS/AQ) is, next to the fixed-dose combination of artemether-lumefantrine, the most widely adopted artemisinin combination therapy (ACT) regimen being used as first-line therapy for uncomplicated malaria by National Malaria Control Programs in sub-Saharan Africa. In contrast to other ACT regimens in current use, on which reviews of the available evidence on safety and efficacy have been periodically published, no, or few summaries of the extensive data available on the safety and efficacy of this widely used ACT are available in the published literature. The available evidence on AS/AQ indicates high efficacy of this combination in children, variable tolerability in adults, and an interaction between artesunate and amodiaquine that could have implications for medium term efficacy or safety of the combination. In this article, a review of the available evidence on the efficacy and safety on AS/AQ, with a particular focus on parameters that could have operational significance for malaria control in endemic areas, is presented and discussed.
AB - The combination of artesunate plus amodiaquine (AS/AQ) is, next to the fixed-dose combination of artemether-lumefantrine, the most widely adopted artemisinin combination therapy (ACT) regimen being used as first-line therapy for uncomplicated malaria by National Malaria Control Programs in sub-Saharan Africa. In contrast to other ACT regimens in current use, on which reviews of the available evidence on safety and efficacy have been periodically published, no, or few summaries of the extensive data available on the safety and efficacy of this widely used ACT are available in the published literature. The available evidence on AS/AQ indicates high efficacy of this combination in children, variable tolerability in adults, and an interaction between artesunate and amodiaquine that could have implications for medium term efficacy or safety of the combination. In this article, a review of the available evidence on the efficacy and safety on AS/AQ, with a particular focus on parameters that could have operational significance for malaria control in endemic areas, is presented and discussed.
KW - Artemisinin combination therapy
KW - Artesunate-amodiaquine
KW - Uncomplicated malaria
UR - http://www.scopus.com/inward/record.url?scp=76749083338&partnerID=8YFLogxK
U2 - 10.1002/ddr.20346
DO - 10.1002/ddr.20346
M3 - Review article
AN - SCOPUS:76749083338
SN - 0272-4391
VL - 71
SP - 33
EP - 43
JO - Drug Development Research
JF - Drug Development Research
IS - 1
ER -