Antiplasmodial constituents from the stem bark of Polyalthia longifolia var pendula

Kofi Annan; Edmund Ekuadzi; Cindy Asare; Kwame Sarpong; Dominik Pistorius; Lukas Oberer; Ben A. Gyan; Michael Ofori

doi:10.1016/j.phytol.2014.10.028

Antiplasmodial constituents from the stem bark of Polyalthia longifolia var pendula

Kofi Annan
, Edmund Ekuadzi
, Cindy Asare
, Kwame Sarpong
, Dominik Pistorius
, Lukas Oberer
, Ben A. Gyan
, Michael Ofori

Kwame Nkrumah University of Science and Technology
Novartis International AG
Noguchi Memorial Institute for Medical Research

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Along with two known compounds (1 and 2), four new clerodane diterpenes were isolated and identified from the stem bark of Polyalthia longifolia: cleroda-3-ene pyrrole-15,16-dione (3), cleroda-3-ene, pyrrolidine-15,16-dione (4), cleroda-3,13(14)E-diene-15,16-diamide (5), and cleroda-3-ene-15,16-diamide (6). Their structures were elucidated by combinations of NMR, MS and IR. Using the WHO Mark III Microtest assay, the isolated compounds were evaluated for their antiplasmodial effects. They showed antiplasmodial effects, with IC₅₀s ranging from 4.5 to 213.8 μM.

Original language	English
Pages (from-to)	28-31
Number of pages	4
Journal	Phytochemistry Letters
Volume	11
DOIs	https://doi.org/10.1016/j.phytol.2014.10.028
Publication status	Published - Mar 2015
Externally published	Yes

Keywords

Antiplasmodial
Bisclerodane imide
Clerodane
Diterpenes
Polyalthia longifolia

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10.1016/j.phytol.2014.10.028

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title = "Antiplasmodial constituents from the stem bark of Polyalthia longifolia var pendula",

abstract = "Along with two known compounds (1 and 2), four new clerodane diterpenes were isolated and identified from the stem bark of Polyalthia longifolia: cleroda-3-ene pyrrole-15,16-dione (3), cleroda-3-ene, pyrrolidine-15,16-dione (4), cleroda-3,13(14)E-diene-15,16-diamide (5), and cleroda-3-ene-15,16-diamide (6). Their structures were elucidated by combinations of NMR, MS and IR. Using the WHO Mark III Microtest assay, the isolated compounds were evaluated for their antiplasmodial effects. They showed antiplasmodial effects, with IC50s ranging from 4.5 to 213.8 μM.",

keywords = "Antiplasmodial, Bisclerodane imide, Clerodane, Diterpenes, Polyalthia longifolia",

author = "Kofi Annan and Edmund Ekuadzi and Cindy Asare and Kwame Sarpong and Dominik Pistorius and Lukas Oberer and Gyan, \{Ben A.\} and Michael Ofori",

year = "2015",

month = mar,

doi = "10.1016/j.phytol.2014.10.028",

language = "English",

volume = "11",

pages = "28--31",

journal = "Phytochemistry Letters",

issn = "1874-3900",

publisher = "Elsevier Ltd.",

}

TY - JOUR

T1 - Antiplasmodial constituents from the stem bark of Polyalthia longifolia var pendula

AU - Annan, Kofi

AU - Ekuadzi, Edmund

AU - Asare, Cindy

AU - Sarpong, Kwame

AU - Pistorius, Dominik

AU - Oberer, Lukas

AU - Gyan, Ben A.

AU - Ofori, Michael

PY - 2015/3

Y1 - 2015/3

N2 - Along with two known compounds (1 and 2), four new clerodane diterpenes were isolated and identified from the stem bark of Polyalthia longifolia: cleroda-3-ene pyrrole-15,16-dione (3), cleroda-3-ene, pyrrolidine-15,16-dione (4), cleroda-3,13(14)E-diene-15,16-diamide (5), and cleroda-3-ene-15,16-diamide (6). Their structures were elucidated by combinations of NMR, MS and IR. Using the WHO Mark III Microtest assay, the isolated compounds were evaluated for their antiplasmodial effects. They showed antiplasmodial effects, with IC50s ranging from 4.5 to 213.8 μM.

AB - Along with two known compounds (1 and 2), four new clerodane diterpenes were isolated and identified from the stem bark of Polyalthia longifolia: cleroda-3-ene pyrrole-15,16-dione (3), cleroda-3-ene, pyrrolidine-15,16-dione (4), cleroda-3,13(14)E-diene-15,16-diamide (5), and cleroda-3-ene-15,16-diamide (6). Their structures were elucidated by combinations of NMR, MS and IR. Using the WHO Mark III Microtest assay, the isolated compounds were evaluated for their antiplasmodial effects. They showed antiplasmodial effects, with IC50s ranging from 4.5 to 213.8 μM.

KW - Antiplasmodial

KW - Bisclerodane imide

KW - Clerodane

KW - Diterpenes

KW - Polyalthia longifolia

UR - https://www.scopus.com/pages/publications/84913554181

U2 - 10.1016/j.phytol.2014.10.028

DO - 10.1016/j.phytol.2014.10.028

M3 - Article

AN - SCOPUS:84913554181

SN - 1874-3900

VL - 11

SP - 28

EP - 31

JO - Phytochemistry Letters

JF - Phytochemistry Letters

ER -

Antiplasmodial constituents from the stem bark of Polyalthia longifolia var pendula

Abstract

Keywords

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