TY - JOUR
T1 - Antiplasmodial constituents from the stem bark of Polyalthia longifolia var pendula
AU - Annan, Kofi
AU - Ekuadzi, Edmund
AU - Asare, Cindy
AU - Sarpong, Kwame
AU - Pistorius, Dominik
AU - Oberer, Lukas
AU - Gyan, Ben A.
AU - Ofori, Michael
N1 - Publisher Copyright:
© 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
PY - 2015/3
Y1 - 2015/3
N2 - Along with two known compounds (1 and 2), four new clerodane diterpenes were isolated and identified from the stem bark of Polyalthia longifolia: cleroda-3-ene pyrrole-15,16-dione (3), cleroda-3-ene, pyrrolidine-15,16-dione (4), cleroda-3,13(14)E-diene-15,16-diamide (5), and cleroda-3-ene-15,16-diamide (6). Their structures were elucidated by combinations of NMR, MS and IR. Using the WHO Mark III Microtest assay, the isolated compounds were evaluated for their antiplasmodial effects. They showed antiplasmodial effects, with IC50s ranging from 4.5 to 213.8 μM.
AB - Along with two known compounds (1 and 2), four new clerodane diterpenes were isolated and identified from the stem bark of Polyalthia longifolia: cleroda-3-ene pyrrole-15,16-dione (3), cleroda-3-ene, pyrrolidine-15,16-dione (4), cleroda-3,13(14)E-diene-15,16-diamide (5), and cleroda-3-ene-15,16-diamide (6). Their structures were elucidated by combinations of NMR, MS and IR. Using the WHO Mark III Microtest assay, the isolated compounds were evaluated for their antiplasmodial effects. They showed antiplasmodial effects, with IC50s ranging from 4.5 to 213.8 μM.
KW - Antiplasmodial
KW - Bisclerodane imide
KW - Clerodane
KW - Diterpenes
KW - Polyalthia longifolia
UR - http://www.scopus.com/inward/record.url?scp=84913554181&partnerID=8YFLogxK
U2 - 10.1016/j.phytol.2014.10.028
DO - 10.1016/j.phytol.2014.10.028
M3 - Article
AN - SCOPUS:84913554181
SN - 1874-3900
VL - 11
SP - 28
EP - 31
JO - Phytochemistry Letters
JF - Phytochemistry Letters
ER -