TY - JOUR
T1 - Antileishmanial anthraquinones from the rhyzomes of Rumex abyssinicus Jacq (Polygonaceae)
AU - Guetchueng, Stephanie Tamdem
AU - Djouonzo, Paul Toukam
AU - Lame, Younoussa
AU - Kopa Kowa, Théodora
AU - Dotse, Eunice
AU - Tchokouaha, Lauve R.Y.
AU - Kamdem Wabo, Hippolyte
AU - Appiah-Opong, Regina
AU - Agbor, Gabriel Agbor
N1 - Publisher Copyright:
© 2022 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2023
Y1 - 2023
N2 - Phytochemical investigation of the rhyzomes of Rumex abyssinicus (Polygonaceae) afforded six anthraquinones viz chrysophanol (1), physcion (2), emodin (3), mixture of physcion-8-O-β,D-glucopyranoside (4) and chrypsophanol-8-O-β,D-glucopyranoside (5), and emodin-8-O-β,D-glucopyranoside (6). All the compounds were characterised and identified by comparison of their MS and NMR data with available literature data. The isolated compounds were evaluated for their antileishmanial activity. Emodin (3) was the most active compounds with IC50 13.82 and 0.26µg/mL against Leishmania donovani amastigotes and promastigotes, respectively. Emodin-8-O-β,D-glucopyranoside (6) also showed a moderate activity with IC50 27.53 and 37.08 µg/mL. This is the first report of antileishmanial compounds from R. abyssinicus and the antileishmanial activities of compounds 2, 4, 5 and 6 are here reported for the first time.
AB - Phytochemical investigation of the rhyzomes of Rumex abyssinicus (Polygonaceae) afforded six anthraquinones viz chrysophanol (1), physcion (2), emodin (3), mixture of physcion-8-O-β,D-glucopyranoside (4) and chrypsophanol-8-O-β,D-glucopyranoside (5), and emodin-8-O-β,D-glucopyranoside (6). All the compounds were characterised and identified by comparison of their MS and NMR data with available literature data. The isolated compounds were evaluated for their antileishmanial activity. Emodin (3) was the most active compounds with IC50 13.82 and 0.26µg/mL against Leishmania donovani amastigotes and promastigotes, respectively. Emodin-8-O-β,D-glucopyranoside (6) also showed a moderate activity with IC50 27.53 and 37.08 µg/mL. This is the first report of antileishmanial compounds from R. abyssinicus and the antileishmanial activities of compounds 2, 4, 5 and 6 are here reported for the first time.
KW - Rumex abyssinicus
KW - anthraquinones
KW - antileishmanial activity
UR - http://www.scopus.com/inward/record.url?scp=85141062628&partnerID=8YFLogxK
U2 - 10.1080/14786419.2022.2137797
DO - 10.1080/14786419.2022.2137797
M3 - Article
C2 - 36282890
AN - SCOPUS:85141062628
SN - 1478-6419
VL - 37
SP - 2935
EP - 2939
JO - Natural Product Research
JF - Natural Product Research
IS - 17
ER -