Antileishmanial anthraquinones from the rhyzomes of Rumex abyssinicus Jacq (Polygonaceae)

Stephanie Tamdem Guetchueng, Paul Toukam Djouonzo, Younoussa Lame, Théodora Kopa Kowa, Eunice Dotse, Lauve R.Y. Tchokouaha, Hippolyte Kamdem Wabo, Regina Appiah-Opong, Gabriel Agbor Agbor

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Phytochemical investigation of the rhyzomes of Rumex abyssinicus (Polygonaceae) afforded six anthraquinones viz chrysophanol (1), physcion (2), emodin (3), mixture of physcion-8-O-β,D-glucopyranoside (4) and chrypsophanol-8-O-β,D-glucopyranoside (5), and emodin-8-O-β,D-glucopyranoside (6). All the compounds were characterised and identified by comparison of their MS and NMR data with available literature data. The isolated compounds were evaluated for their antileishmanial activity. Emodin (3) was the most active compounds with IC50 13.82 and 0.26µg/mL against Leishmania donovani amastigotes and promastigotes, respectively. Emodin-8-O-β,D-glucopyranoside (6) also showed a moderate activity with IC50 27.53 and 37.08 µg/mL. This is the first report of antileishmanial compounds from R. abyssinicus and the antileishmanial activities of compounds 2, 4, 5 and 6 are here reported for the first time.

Original languageEnglish
Pages (from-to)2935-2939
Number of pages5
JournalNatural Product Research
Volume37
Issue number17
DOIs
Publication statusPublished - 2023
Externally publishedYes

Keywords

  • Rumex abyssinicus
  • anthraquinones
  • antileishmanial activity

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