Antigenicity and immune correlate assessment of seven Plasmodium falciparum antigens in a longitudinal infant cohort from northern Ghana

Kwadwo Asamoah Kusi; Joao Aguiar; Selassie Kumordjie; Felix Aggor; Jessica Bolton; Andrea Renner; Eric Kyei-Baafour; Naiki Puplampu; Maria Belmonte; Daniel Dodoo; Ben Adu Gyan; Michael Fokuo Ofori; Abraham Rex Oduro; Frank Atuguba; Kwadwo Ansah Koram; Nehkonti Adams; Andrew Letizia; Eileen Villasante; Martha Sedegah

doi:10.1038/s41598-019-45092-4

Antigenicity and immune correlate assessment of seven Plasmodium falciparum antigens in a longitudinal infant cohort from northern Ghana

Kwadwo Asamoah Kusi, Joao Aguiar, Selassie Kumordjie, Felix Aggor, Jessica Bolton, Andrea Renner, Eric Kyei-Baafour, Naiki Puplampu, Maria Belmonte, Daniel Dodoo, Ben Adu Gyan, Michael Fokuo Ofori, Abraham Rex Oduro, Frank Atuguba, Kwadwo Ansah Koram, Nehkonti Adams, Andrew Letizia, Eileen Villasante, Martha Sedegah

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Abstract

The current global malaria control and elimination agenda requires development of additional effective disease intervention tools. Discovery and characterization of relevant parasite antigens is important for the development of new diagnostics and transmission monitoring tools and for subunit vaccine development. This study assessed the natural antibody response profile of seven novel Plasmodium falciparum pre-erythrocytic antigens and their potential association with protection against clinical malaria. Antigen-specific antibody levels in plasma collected at six time points from a longitudinal cohort of one-to-five year old children resident in a seasonal malaria transmission area of northern Ghana were assessed by ELISA. Antibody levels were compared between parasite-positive and parasite-negative individuals and the association of antibody levels with malaria risk assessed using a regression model. Plasma antibody levels against five of the seven antigens were significantly higher in parasite-positive children compared to parasite-negative children, especially during low transmission periods. None of the antigen-specific antibodies showed an association with protection against clinical malaria. The study identified five of the seven antigens as markers of exposure to malaria, and these will have relevance for the development of disease diagnostic and monitoring tools. The vaccine potential of these antigens requires further assessment.

Original language	English
Article number	8621
Journal	Scientific Reports
Volume	9
Issue number	1
DOIs	https://doi.org/10.1038/s41598-019-45092-4
Publication status	Published - 1 Dec 2019
Externally published	Yes

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Kusi, K. A., Aguiar, J., Kumordjie, S., Aggor, F., Bolton, J., Renner, A., Kyei-Baafour, E., Puplampu, N., Belmonte, M., Dodoo, D., Gyan, B. A., Ofori, M. F., Oduro, A. R., Atuguba, F., Koram, K. A., Adams, N., Letizia, A., Villasante, E., & Sedegah, M. (2019). Antigenicity and immune correlate assessment of seven Plasmodium falciparum antigens in a longitudinal infant cohort from northern Ghana. Scientific Reports, 9(1), Article 8621. https://doi.org/10.1038/s41598-019-45092-4

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title = "Antigenicity and immune correlate assessment of seven Plasmodium falciparum antigens in a longitudinal infant cohort from northern Ghana",

abstract = "The current global malaria control and elimination agenda requires development of additional effective disease intervention tools. Discovery and characterization of relevant parasite antigens is important for the development of new diagnostics and transmission monitoring tools and for subunit vaccine development. This study assessed the natural antibody response profile of seven novel Plasmodium falciparum pre-erythrocytic antigens and their potential association with protection against clinical malaria. Antigen-specific antibody levels in plasma collected at six time points from a longitudinal cohort of one-to-five year old children resident in a seasonal malaria transmission area of northern Ghana were assessed by ELISA. Antibody levels were compared between parasite-positive and parasite-negative individuals and the association of antibody levels with malaria risk assessed using a regression model. Plasma antibody levels against five of the seven antigens were significantly higher in parasite-positive children compared to parasite-negative children, especially during low transmission periods. None of the antigen-specific antibodies showed an association with protection against clinical malaria. The study identified five of the seven antigens as markers of exposure to malaria, and these will have relevance for the development of disease diagnostic and monitoring tools. The vaccine potential of these antigens requires further assessment.",

author = "Kusi, {Kwadwo Asamoah} and Joao Aguiar and Selassie Kumordjie and Felix Aggor and Jessica Bolton and Andrea Renner and Eric Kyei-Baafour and Naiki Puplampu and Maria Belmonte and Daniel Dodoo and Gyan, {Ben Adu} and Ofori, {Michael Fokuo} and Oduro, {Abraham Rex} and Frank Atuguba and Koram, {Kwadwo Ansah} and Nehkonti Adams and Andrew Letizia and Eileen Villasante and Martha Sedegah",

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doi = "10.1038/s41598-019-45092-4",

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Kusi, KA, Aguiar, J, Kumordjie, S, Aggor, F, Bolton, J, Renner, A, Kyei-Baafour, E, Puplampu, N, Belmonte, M, Dodoo, D, Gyan, BA, Ofori, MF, Oduro, AR, Atuguba, F, Koram, KA, Adams, N, Letizia, A, Villasante, E & Sedegah, M 2019, 'Antigenicity and immune correlate assessment of seven Plasmodium falciparum antigens in a longitudinal infant cohort from northern Ghana', Scientific Reports, vol. 9, no. 1, 8621. https://doi.org/10.1038/s41598-019-45092-4

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T1 - Antigenicity and immune correlate assessment of seven Plasmodium falciparum antigens in a longitudinal infant cohort from northern Ghana

AU - Kusi, Kwadwo Asamoah

AU - Aguiar, Joao

AU - Kumordjie, Selassie

AU - Aggor, Felix

AU - Bolton, Jessica

AU - Renner, Andrea

AU - Kyei-Baafour, Eric

AU - Puplampu, Naiki

AU - Belmonte, Maria

AU - Dodoo, Daniel

AU - Gyan, Ben Adu

AU - Ofori, Michael Fokuo

AU - Oduro, Abraham Rex

AU - Atuguba, Frank

AU - Koram, Kwadwo Ansah

AU - Adams, Nehkonti

AU - Letizia, Andrew

AU - Villasante, Eileen

AU - Sedegah, Martha

PY - 2019/12/1

Y1 - 2019/12/1

N2 - The current global malaria control and elimination agenda requires development of additional effective disease intervention tools. Discovery and characterization of relevant parasite antigens is important for the development of new diagnostics and transmission monitoring tools and for subunit vaccine development. This study assessed the natural antibody response profile of seven novel Plasmodium falciparum pre-erythrocytic antigens and their potential association with protection against clinical malaria. Antigen-specific antibody levels in plasma collected at six time points from a longitudinal cohort of one-to-five year old children resident in a seasonal malaria transmission area of northern Ghana were assessed by ELISA. Antibody levels were compared between parasite-positive and parasite-negative individuals and the association of antibody levels with malaria risk assessed using a regression model. Plasma antibody levels against five of the seven antigens were significantly higher in parasite-positive children compared to parasite-negative children, especially during low transmission periods. None of the antigen-specific antibodies showed an association with protection against clinical malaria. The study identified five of the seven antigens as markers of exposure to malaria, and these will have relevance for the development of disease diagnostic and monitoring tools. The vaccine potential of these antigens requires further assessment.

AB - The current global malaria control and elimination agenda requires development of additional effective disease intervention tools. Discovery and characterization of relevant parasite antigens is important for the development of new diagnostics and transmission monitoring tools and for subunit vaccine development. This study assessed the natural antibody response profile of seven novel Plasmodium falciparum pre-erythrocytic antigens and their potential association with protection against clinical malaria. Antigen-specific antibody levels in plasma collected at six time points from a longitudinal cohort of one-to-five year old children resident in a seasonal malaria transmission area of northern Ghana were assessed by ELISA. Antibody levels were compared between parasite-positive and parasite-negative individuals and the association of antibody levels with malaria risk assessed using a regression model. Plasma antibody levels against five of the seven antigens were significantly higher in parasite-positive children compared to parasite-negative children, especially during low transmission periods. None of the antigen-specific antibodies showed an association with protection against clinical malaria. The study identified five of the seven antigens as markers of exposure to malaria, and these will have relevance for the development of disease diagnostic and monitoring tools. The vaccine potential of these antigens requires further assessment.

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DO - 10.1038/s41598-019-45092-4

M3 - Article

C2 - 31197225

AN - SCOPUS:85067340293

SN - 2045-2322

VL - 9

JO - Scientific Reports

JF - Scientific Reports

IS - 1

M1 - 8621

ER -

Antigenicity and immune correlate assessment of seven Plasmodium falciparum antigens in a longitudinal infant cohort from northern Ghana

Abstract

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