Antibody-dependent cellular inhibition is associated with reduced risk against Febrile malaria in a longitudinal cohort study involving Ghanaian children

Regis W. Tiendrebeogo; Bright Adu; Susheel K. Singh; Morten H. Dziegiel; Issa Nébié; Sodiomon B. Sirima; Michael Christiansen; Daniel Dodoo; Michael Theisen

doi:10.1093/ofid/ofv044

Antibody-dependent cellular inhibition is associated with reduced risk against Febrile malaria in a longitudinal cohort study involving Ghanaian children

Regis W. Tiendrebeogo, Bright Adu, Susheel K. Singh, Morten H. Dziegiel, Issa Nébié, Sodiomon B. Sirima, Michael Christiansen, Daniel Dodoo, Michael Theisen

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

The antibody-dependent respiratory burst and opsonic phagocytosis assays have been associated with protection against malaria; however, other mechanisms may also be involved. The antibody-dependent cellular inhibition (ADCI) assay is yet to be correlated with protection in longitudinal cohort studies (LCS). We investigated the relationship between ADCI activity of immunoglobulin G before malaria season and risk of malaria in a LCS involving Ghanaian children. High ADCI activity was significantly associated with reduced risk against malaria. Findings here suggest a potential usefulness of the ADCI assay as a correlate of protection to guide malaria vaccine studies.

Original language	English
Journal	Open Forum Infectious Diseases
Volume	2
Issue number	2
DOIs	https://doi.org/10.1093/ofid/ofv044
Publication status	Published - 1 Apr 2015
Externally published	Yes

Keywords

Children
Longitudinal cohort study
Malaria
Monocytes
Plasmodium falciparum
antibody-dependent cellular inhibition

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1093/ofid/ofv044

Cite this

@article{ae8cea027ccd4ccabe900fcb22f6f0f7,

title = "Antibody-dependent cellular inhibition is associated with reduced risk against Febrile malaria in a longitudinal cohort study involving Ghanaian children",

abstract = "The antibody-dependent respiratory burst and opsonic phagocytosis assays have been associated with protection against malaria; however, other mechanisms may also be involved. The antibody-dependent cellular inhibition (ADCI) assay is yet to be correlated with protection in longitudinal cohort studies (LCS). We investigated the relationship between ADCI activity of immunoglobulin G before malaria season and risk of malaria in a LCS involving Ghanaian children. High ADCI activity was significantly associated with reduced risk against malaria. Findings here suggest a potential usefulness of the ADCI assay as a correlate of protection to guide malaria vaccine studies.",

keywords = "Children, Longitudinal cohort study, Malaria, Monocytes, Plasmodium falciparum, antibody-dependent cellular inhibition",

author = "Tiendrebeogo, \{Regis W.\} and Bright Adu and Singh, \{Susheel K.\} and Dziegiel, \{Morten H.\} and Issa N{\'e}bi{\'e} and Sirima, \{Sodiomon B.\} and Michael Christiansen and Daniel Dodoo and Michael Theisen",

note = "Publisher Copyright: {\textcopyright} The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Societyof America.",

year = "2015",

month = apr,

day = "1",

doi = "10.1093/ofid/ofv044",

language = "English",

volume = "2",

journal = "Open Forum Infectious Diseases",

issn = "2328-8957",

publisher = "Oxford University Press",

number = "2",

}

TY - JOUR

T1 - Antibody-dependent cellular inhibition is associated with reduced risk against Febrile malaria in a longitudinal cohort study involving Ghanaian children

AU - Tiendrebeogo, Regis W.

AU - Adu, Bright

AU - Singh, Susheel K.

AU - Dziegiel, Morten H.

AU - Nébié, Issa

AU - Sirima, Sodiomon B.

AU - Christiansen, Michael

AU - Dodoo, Daniel

AU - Theisen, Michael

N1 - Publisher Copyright: © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Societyof America.

PY - 2015/4/1

Y1 - 2015/4/1

N2 - The antibody-dependent respiratory burst and opsonic phagocytosis assays have been associated with protection against malaria; however, other mechanisms may also be involved. The antibody-dependent cellular inhibition (ADCI) assay is yet to be correlated with protection in longitudinal cohort studies (LCS). We investigated the relationship between ADCI activity of immunoglobulin G before malaria season and risk of malaria in a LCS involving Ghanaian children. High ADCI activity was significantly associated with reduced risk against malaria. Findings here suggest a potential usefulness of the ADCI assay as a correlate of protection to guide malaria vaccine studies.

AB - The antibody-dependent respiratory burst and opsonic phagocytosis assays have been associated with protection against malaria; however, other mechanisms may also be involved. The antibody-dependent cellular inhibition (ADCI) assay is yet to be correlated with protection in longitudinal cohort studies (LCS). We investigated the relationship between ADCI activity of immunoglobulin G before malaria season and risk of malaria in a LCS involving Ghanaian children. High ADCI activity was significantly associated with reduced risk against malaria. Findings here suggest a potential usefulness of the ADCI assay as a correlate of protection to guide malaria vaccine studies.

KW - Children

KW - Longitudinal cohort study

KW - Malaria

KW - Monocytes

KW - Plasmodium falciparum

KW - antibody-dependent cellular inhibition

UR - https://www.scopus.com/pages/publications/84978327821

U2 - 10.1093/ofid/ofv044

DO - 10.1093/ofid/ofv044

M3 - Article

AN - SCOPUS:84978327821

SN - 2328-8957

VL - 2

JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

IS - 2

ER -

Antibody-dependent cellular inhibition is associated with reduced risk against Febrile malaria in a longitudinal cohort study involving Ghanaian children

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this