Antibody-dependent cellular inhibition is associated with reduced risk against Febrile malaria in a longitudinal cohort study involving Ghanaian children

Regis W. Tiendrebeogo; Bright Adu; Susheel K. Singh; Morten H. Dziegiel; Issa Nébié; Sodiomon B. Sirima; Michael Christiansen; Daniel Dodoo; Michael Theisen

doi:10.1093/ofid/ofv044

Antibody-dependent cellular inhibition is associated with reduced risk against Febrile malaria in a longitudinal cohort study involving Ghanaian children

Regis W. Tiendrebeogo
, Bright Adu
, Susheel K. Singh
, Morten H. Dziegiel
, Issa Nébié
, Sodiomon B. Sirima
, Michael Christiansen
, Daniel Dodoo
, Michael Theisen

Statens Serum Institut
University of Copenhagen
University of Ghana
Centre National de Recherche et de Formation sur le Paludisme

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

The antibody-dependent respiratory burst and opsonic phagocytosis assays have been associated with protection against malaria; however, other mechanisms may also be involved. The antibody-dependent cellular inhibition (ADCI) assay is yet to be correlated with protection in longitudinal cohort studies (LCS). We investigated the relationship between ADCI activity of immunoglobulin G before malaria season and risk of malaria in a LCS involving Ghanaian children. High ADCI activity was significantly associated with reduced risk against malaria. Findings here suggest a potential usefulness of the ADCI assay as a correlate of protection to guide malaria vaccine studies.

Original language	English
Journal	Open Forum Infectious Diseases
Volume	2
Issue number	2
DOIs	https://doi.org/10.1093/ofid/ofv044
Publication status	Published - 1 Apr 2015
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Children
Longitudinal cohort study
Malaria
Monocytes
Plasmodium falciparum
antibody-dependent cellular inhibition

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10.1093/ofid/ofv044

Cite this

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title = "Antibody-dependent cellular inhibition is associated with reduced risk against Febrile malaria in a longitudinal cohort study involving Ghanaian children",

abstract = "The antibody-dependent respiratory burst and opsonic phagocytosis assays have been associated with protection against malaria; however, other mechanisms may also be involved. The antibody-dependent cellular inhibition (ADCI) assay is yet to be correlated with protection in longitudinal cohort studies (LCS). We investigated the relationship between ADCI activity of immunoglobulin G before malaria season and risk of malaria in a LCS involving Ghanaian children. High ADCI activity was significantly associated with reduced risk against malaria. Findings here suggest a potential usefulness of the ADCI assay as a correlate of protection to guide malaria vaccine studies.",

keywords = "Children, Longitudinal cohort study, Malaria, Monocytes, Plasmodium falciparum, antibody-dependent cellular inhibition",

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doi = "10.1093/ofid/ofv044",

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T1 - Antibody-dependent cellular inhibition is associated with reduced risk against Febrile malaria in a longitudinal cohort study involving Ghanaian children

AU - Tiendrebeogo, Regis W.

AU - Adu, Bright

AU - Singh, Susheel K.

AU - Dziegiel, Morten H.

AU - Nébié, Issa

AU - Sirima, Sodiomon B.

AU - Christiansen, Michael

AU - Dodoo, Daniel

AU - Theisen, Michael

PY - 2015/4/1

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AB - The antibody-dependent respiratory burst and opsonic phagocytosis assays have been associated with protection against malaria; however, other mechanisms may also be involved. The antibody-dependent cellular inhibition (ADCI) assay is yet to be correlated with protection in longitudinal cohort studies (LCS). We investigated the relationship between ADCI activity of immunoglobulin G before malaria season and risk of malaria in a LCS involving Ghanaian children. High ADCI activity was significantly associated with reduced risk against malaria. Findings here suggest a potential usefulness of the ADCI assay as a correlate of protection to guide malaria vaccine studies.

KW - Children

KW - Longitudinal cohort study

KW - Malaria

KW - Monocytes

KW - Plasmodium falciparum

KW - antibody-dependent cellular inhibition

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DO - 10.1093/ofid/ofv044

M3 - Article

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SN - 2328-8957

VL - 2

JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

IS - 2

ER -

Antibody-dependent cellular inhibition is associated with reduced risk against Febrile malaria in a longitudinal cohort study involving Ghanaian children

Abstract

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Keywords

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