TY - JOUR
T1 - Antibiotic prescribing patterns in Ghana, Uganda, Zambia and Tanzania hospitals
T2 - Results from the global point prevalence survey (G-PPS) on antimicrobial use and stewardship interventions implemented
AU - D’Arcy, Nikki
AU - Ashiru-Oredope, Diane
AU - Olaoye, Omotayo
AU - Afriyie, Daniel
AU - Akello, Zainab
AU - Ankrah, Daniel
AU - Asima, Derrickmawuena
AU - Banda, David C.
AU - Barrett, Scott
AU - Brandish, Claire
AU - Brayson, Joseph
AU - Benedict, Peter
AU - Dodoo, Cornelius C.
AU - Garraghan, Frances
AU - Hoyelah, Josephyn
AU - Jani, Yogini
AU - Kitutu, Freddy Eric
AU - Kizito, Ismail Musoke
AU - Labi, Appiah Korang
AU - Mirfenderesky, Mariyam
AU - Murdan, Sudaxshina
AU - Murray, Caoimhe
AU - Obeng-Nkrumah, Noah
AU - Olum, William J’Pathim
AU - Opintan, Japheth Awuletey
AU - Panford-Quainoo, Edwin
AU - Pauwels, Ines
AU - Sefah, Israel
AU - Sneddon, Jacqueline
AU - Clair Jones, Anja St
AU - Versporten, Ann
N1 - Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/9
Y1 - 2021/9
N2 - Antimicrobial resistance (AMR) remains an important global public health issue with antimicrobial misuse and overuse being one of the main drivers. The Global Point Prevalence Survey (G-PPS) of Antimicrobial Consumption and Resistance assesses the prevalence and the quality of antimicrobial prescriptions across hospitals globally. G-PPS was carried out at 17 hospitals across Ghana, Uganda, Zambia and Tanzania. The overall prevalence of antimicrobial use was 50% (30-57%), with most antibiotics prescribed belonging to the WHO ‘Access’ and ‘Watch’ categories. No ‘Reserve’ category of antibiotics was prescribed across the study sites while antimicrobials belonging to the ‘Not Recommended’ group were prescribed infrequently. Antimicrobials were most often prescribed for prophylaxis for obstetric or gynaecological surgery, making up between 12 and 18% of total prescriptions across all countries. The most prescribed therapeutic subgroup of antimicrobials was ‘Antibacterials for systemic use’. As a result of the programme, PPS data are now readily available for the first time in the hospitals, strengthening the global commitment to improved antimicrobial surveillance. Antimicrobial stewardship interventions developed included the formation of AMS committees, the provision of training and the preparation of new AMS guidelines. Other common interventions included the presentation of findings to clinicians for increased awareness, and the promotion of a multi-disciplinary approach to successful AMS programmes. Repeat PPS would be necessary to continually monitor the impact of interventions implemented. Broader participation is also encouraged to strengthen the evidence base.
AB - Antimicrobial resistance (AMR) remains an important global public health issue with antimicrobial misuse and overuse being one of the main drivers. The Global Point Prevalence Survey (G-PPS) of Antimicrobial Consumption and Resistance assesses the prevalence and the quality of antimicrobial prescriptions across hospitals globally. G-PPS was carried out at 17 hospitals across Ghana, Uganda, Zambia and Tanzania. The overall prevalence of antimicrobial use was 50% (30-57%), with most antibiotics prescribed belonging to the WHO ‘Access’ and ‘Watch’ categories. No ‘Reserve’ category of antibiotics was prescribed across the study sites while antimicrobials belonging to the ‘Not Recommended’ group were prescribed infrequently. Antimicrobials were most often prescribed for prophylaxis for obstetric or gynaecological surgery, making up between 12 and 18% of total prescriptions across all countries. The most prescribed therapeutic subgroup of antimicrobials was ‘Antibacterials for systemic use’. As a result of the programme, PPS data are now readily available for the first time in the hospitals, strengthening the global commitment to improved antimicrobial surveillance. Antimicrobial stewardship interventions developed included the formation of AMS committees, the provision of training and the preparation of new AMS guidelines. Other common interventions included the presentation of findings to clinicians for increased awareness, and the promotion of a multi-disciplinary approach to successful AMS programmes. Repeat PPS would be necessary to continually monitor the impact of interventions implemented. Broader participation is also encouraged to strengthen the evidence base.
KW - Antibiotics
KW - Antimicrobial resistance
KW - Antimicrobial stewardship
KW - Antimicrobial surveillance
KW - Antimicrobials
KW - Global-pps
UR - http://www.scopus.com/inward/record.url?scp=85116168183&partnerID=8YFLogxK
U2 - 10.3390/antibiotics10091122
DO - 10.3390/antibiotics10091122
M3 - Article
AN - SCOPUS:85116168183
SN - 2079-6382
VL - 10
JO - Antibiotics
JF - Antibiotics
IS - 9
M1 - 1122
ER -