TY - JOUR
T1 - An Analysis of Racial and Ethnic Backgrounds Within the CASiRe International Cohort of Sickle Cell Disease Patients
T2 - Implications for Disease Phenotype and Clinical Research
AU - Campbell, Andrew D.
AU - Colombatti, Raffaella
AU - Andemariam, Biree
AU - Strunk, Crawford
AU - Tartaglione, Immacolata
AU - Piccone, Connie M.
AU - Manwani, Deepa
AU - Asare, Eugenia Vicky
AU - Boruchov, Donna
AU - Farooq, Fatimah
AU - Urbonya, Rebekah
AU - Boatemaa, Gifty Dankwah
AU - Perrotta, Silverio
AU - Sainati, Laura
AU - Rivers, Angela
AU - Rao, Sudha
AU - Zempsky, William
AU - Sey, Fredericka
AU - Segbefia, Catherine
AU - Inusa, Baba
AU - Antwi-Boasiako, Charles
N1 - Publisher Copyright:
© 2020, W. Montague Cobb-NMA Health Institute.
PY - 2021/2
Y1 - 2021/2
N2 - Millions are affected by sickle cell disease (SCD) worldwide with the greatest burden in sub-Saharan Africa. While its origin lies historically within the malaria belt, ongoing changes in migration patterns have shifted the burden of disease resulting in a global public health concern. We created the Consortium for the Advancement of Sickle Cell Research (CASiRe) to understand the different phenotypes of SCD across 4 countries (USA, UK, Italy, and Ghana). Here, we report the multi-generational ethnic and racial background of 877 SCD patients recruited in Ghana (n = 365, 41.6%), the USA (n = 254, 29%), Italy (n = 81, 9.2%), and the UK (n = 177, 20.2%). West Africa (including Benin Gulf) (N = 556, 63.4%) was the most common geographic region of origin, followed by North America (N = 184, 21%), Caribbean (N = 51, 5.8%), Europe (N = 27, 3.1%), Central Africa (N = 24, 2.7%), and West Africa (excluding Benin Gulf) (N = 21, 2.4%). SCD patients in Europe were primarily West African (73%), European (10%), Caribbean (8%), and Central African (8%). In the USA, patients were largely African American (71%), Caribbean (13%), or West African (10%). Most subjects identified themselves as Black or African American; the European cohort had the largest group of Caucasian SCD patients (8%), including 21% of the Italian patients. This is the first report of a comprehensive analysis of ethnicity within an international, transcontinental group of SCD patients. The diverse ethnic backgrounds observed in our cohort raises the possibility that genetic and environmental heterogeneity within each SCD population subgroup can affect the clinical phenotype and research outcomes.
AB - Millions are affected by sickle cell disease (SCD) worldwide with the greatest burden in sub-Saharan Africa. While its origin lies historically within the malaria belt, ongoing changes in migration patterns have shifted the burden of disease resulting in a global public health concern. We created the Consortium for the Advancement of Sickle Cell Research (CASiRe) to understand the different phenotypes of SCD across 4 countries (USA, UK, Italy, and Ghana). Here, we report the multi-generational ethnic and racial background of 877 SCD patients recruited in Ghana (n = 365, 41.6%), the USA (n = 254, 29%), Italy (n = 81, 9.2%), and the UK (n = 177, 20.2%). West Africa (including Benin Gulf) (N = 556, 63.4%) was the most common geographic region of origin, followed by North America (N = 184, 21%), Caribbean (N = 51, 5.8%), Europe (N = 27, 3.1%), Central Africa (N = 24, 2.7%), and West Africa (excluding Benin Gulf) (N = 21, 2.4%). SCD patients in Europe were primarily West African (73%), European (10%), Caribbean (8%), and Central African (8%). In the USA, patients were largely African American (71%), Caribbean (13%), or West African (10%). Most subjects identified themselves as Black or African American; the European cohort had the largest group of Caucasian SCD patients (8%), including 21% of the Italian patients. This is the first report of a comprehensive analysis of ethnicity within an international, transcontinental group of SCD patients. The diverse ethnic backgrounds observed in our cohort raises the possibility that genetic and environmental heterogeneity within each SCD population subgroup can affect the clinical phenotype and research outcomes.
KW - Ethnicity
KW - International
KW - Phenotype
KW - Race
KW - Sickle cell
UR - http://www.scopus.com/inward/record.url?scp=85084829923&partnerID=8YFLogxK
U2 - 10.1007/s40615-020-00762-2
DO - 10.1007/s40615-020-00762-2
M3 - Article
C2 - 32418182
AN - SCOPUS:85084829923
SN - 2197-3792
VL - 8
SP - 99
EP - 106
JO - Journal of racial and ethnic health disparities
JF - Journal of racial and ethnic health disparities
IS - 1
ER -