Adverse lipid profile is not associated with relapse risk in MS: Results from an observational cohort study

Prudence Tettey, Steve Simpson, Bruce Taylor, Leigh Blizzard, Anne Louise Ponsonby, Terence Dwyer, Karam Kostner, Ingrid Van Der Mei

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

Background There is increasing evidence that serum lipids and apolipoproteins may be associated with multiple sclerosis (MS) clinical course. Objective To investigate the associations between serum lipids, apolipoproteins, body mass index and relapse in MS. Methods A prospective cohort of 141 participants with relapsing-remitting MS was followed from 2002 to 2005. Serum lipid and apolipoprotein levels were measured biannually, and body mass index at baseline. The association with hazard of relapse was assessed using survival analysis. Results Neither body mass index nor any of the lipid-related measures were associated with the hazard of relapse. Conclusion Serum lipid profile and body mass index are not associated with the hazard of relapse in MS.

Original languageEnglish
Pages (from-to)230-232
Number of pages3
JournalJournal of the Neurological Sciences
Volume340
Issue number1-2
DOIs
Publication statusPublished - 15 May 2014
Externally publishedYes

Keywords

  • Apolipoprotein
  • Cholesterol
  • Lipid
  • Multiple sclerosis
  • Profile
  • Relapse

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