Admixture into and within sub-Saharan Africa

Malaria Genomic Epidemiology Network

doi:10.7554/eLife.15266.001

Admixture into and within sub-Saharan Africa

Malaria Genomic Epidemiology Network

University of Oxford
Wellcome Sanger Institute
Medical Research Council Unit
Ministry of Health
Medical Research Council Unit at the LSTHM
Centre National de Recherche et de Formation sur le Paludisme
La Sapienza University
Navrongo Health Research Centre
Noguchi Memorial Institute for Medical Research
Komfo Anokye Teaching Hospital
Kwame Nkrumah University of Science and Technology
University of Buea
KEMRI/WELLCOME Trust Research Programme
Kilimanjaro Christian Medical College
London School of Hygiene & Tropical Medicine
College of Medicine
University of Bamako
National Institute for Biological Standards and Control
Wellcome Trust
Bernhard Nocht Insitute for Tropical Medicine
University of Maryland, Baltimore (UMB)
US Department of Health and Human Services
National Institute of Health
Institut Pasteur of Dakar
The Institut Pasteur de Dakar
University of Ibadan
University Of Khatoum
National Institute for Medical Research Tanga
Muhimbili University of Health and Allied Sciences
University of Colombo
Mahidol University
Oxford University Clinical Research Unit
Papua New Guinea Institute of Medical Research

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

Similarity between two individuals in the combination of genetic markers along their chromosomes indicates shared ancestry and can be used to identify historical connections between different population groups due to admixture. We use a genome-wide, haplotype-based, analysis to characterise the structure of genetic diversity and gene-flow in a collection of 48 sub-Saharan African groups. We show that coastal populations experienced an influx of Eurasian haplotypes over the last 7000 years, and that Eastern and Southern Niger-Congo speaking groups share ancestry with Central West Africans as a result of recent population expansions. In fact, most sub-Saharan populations share ancestry with groups from outside of their current geographic region as a result of gene-flow within the last 4000 years. Our in-depth analysis provides insight into haplotype sharing across different ethno-linguistic groups and the recent movement of alleles into new environments, both of which are relevant to studies of genetic epidemiology.

Original language	English
Article number	e15266
Journal	eLife
Volume	5
Issue number	JUN2016
DOIs	https://doi.org/10.7554/eLife.15266.001
Publication status	Published - 21 Jun 2016
Externally published	Yes

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10.7554/eLife.15266.001

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@article{68fc44eb15cb45ef92512885fff3f9b3,

title = "Admixture into and within sub-Saharan Africa",

abstract = "Similarity between two individuals in the combination of genetic markers along their chromosomes indicates shared ancestry and can be used to identify historical connections between different population groups due to admixture. We use a genome-wide, haplotype-based, analysis to characterise the structure of genetic diversity and gene-flow in a collection of 48 sub-Saharan African groups. We show that coastal populations experienced an influx of Eurasian haplotypes over the last 7000 years, and that Eastern and Southern Niger-Congo speaking groups share ancestry with Central West Africans as a result of recent population expansions. In fact, most sub-Saharan populations share ancestry with groups from outside of their current geographic region as a result of gene-flow within the last 4000 years. Our in-depth analysis provides insight into haplotype sharing across different ethno-linguistic groups and the recent movement of alleles into new environments, both of which are relevant to studies of genetic epidemiology.",

author = "\{Malaria Genomic Epidemiology Network\} and Busby, \{George B.J.\} and Gavin Band and Le, \{Quang Si\} and Muminatou Jallow and Edith Bougama and Mangano, \{Valentina D.\} and Amenga-Etego, \{Lucas N.\} and Anthony Enimil and Tobias Apinjoh and Ndila, \{Carolyne M.\} and Alphaxard Manjurano and Vysaul Nyirongo and Ogobara Doumba and Rockett, \{Kirk A.\} and Kwiatkowski, \{Dominic P.\} and Spencer, \{Chris C.A.\} and Aaron Vanderwal and Abier Elzein and Aceme Nyika and Alieu Mendy and Alistair Miles and Andrea Diss and Angeliki Kerasidou and Angie Green and Jeffreys, \{Anna E.\} and Bronwyn MacInnis and Catherine Hughes and Catherine Moyes and Christina Hubbart and Cinzia Malangone and Claire Potter and Daniel Mead and David Barnwell and Dushyanth Jyothi and Eleanor Drury and Elilan Somaskantharajah and Eliza Hilton and Ellen Leffler and Gareth Maslen and George Busby and Clarke, \{Geraldine M.\} and Ioannis Ragoussis and Garcia, \{Jacob Almagro\} and Jane Rogers and Jantina deVries and Jennifer Shelton and Jiannis Ragoussis and Jim Stalker and Joanne Rodford and Anita Ghansah",

note = "Publisher Copyright: {\textcopyright} Busby et al.",

year = "2016",

month = jun,

day = "21",

doi = "10.7554/eLife.15266.001",

language = "English",

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journal = "eLife",

issn = "2050-084X",

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T1 - Admixture into and within sub-Saharan Africa

AU - Malaria Genomic Epidemiology Network

AU - Busby, George B.J.

AU - Band, Gavin

AU - Le, Quang Si

AU - Jallow, Muminatou

AU - Bougama, Edith

AU - Mangano, Valentina D.

AU - Amenga-Etego, Lucas N.

AU - Enimil, Anthony

AU - Apinjoh, Tobias

AU - Ndila, Carolyne M.

AU - Manjurano, Alphaxard

AU - Nyirongo, Vysaul

AU - Doumba, Ogobara

AU - Rockett, Kirk A.

AU - Kwiatkowski, Dominic P.

AU - Spencer, Chris C.A.

AU - Vanderwal, Aaron

AU - Elzein, Abier

AU - Nyika, Aceme

AU - Mendy, Alieu

AU - Miles, Alistair

AU - Diss, Andrea

AU - Kerasidou, Angeliki

AU - Green, Angie

AU - Jeffreys, Anna E.

AU - MacInnis, Bronwyn

AU - Hughes, Catherine

AU - Moyes, Catherine

AU - Hubbart, Christina

AU - Malangone, Cinzia

AU - Potter, Claire

AU - Mead, Daniel

AU - Barnwell, David

AU - Jyothi, Dushyanth

AU - Drury, Eleanor

AU - Somaskantharajah, Elilan

AU - Hilton, Eliza

AU - Leffler, Ellen

AU - Maslen, Gareth

AU - Busby, George

AU - Clarke, Geraldine M.

AU - Ragoussis, Ioannis

AU - Garcia, Jacob Almagro

AU - Rogers, Jane

AU - deVries, Jantina

AU - Shelton, Jennifer

AU - Ragoussis, Jiannis

AU - Stalker, Jim

AU - Rodford, Joanne

AU - Ghansah, Anita

PY - 2016/6/21

Y1 - 2016/6/21

N2 - Similarity between two individuals in the combination of genetic markers along their chromosomes indicates shared ancestry and can be used to identify historical connections between different population groups due to admixture. We use a genome-wide, haplotype-based, analysis to characterise the structure of genetic diversity and gene-flow in a collection of 48 sub-Saharan African groups. We show that coastal populations experienced an influx of Eurasian haplotypes over the last 7000 years, and that Eastern and Southern Niger-Congo speaking groups share ancestry with Central West Africans as a result of recent population expansions. In fact, most sub-Saharan populations share ancestry with groups from outside of their current geographic region as a result of gene-flow within the last 4000 years. Our in-depth analysis provides insight into haplotype sharing across different ethno-linguistic groups and the recent movement of alleles into new environments, both of which are relevant to studies of genetic epidemiology.

AB - Similarity between two individuals in the combination of genetic markers along their chromosomes indicates shared ancestry and can be used to identify historical connections between different population groups due to admixture. We use a genome-wide, haplotype-based, analysis to characterise the structure of genetic diversity and gene-flow in a collection of 48 sub-Saharan African groups. We show that coastal populations experienced an influx of Eurasian haplotypes over the last 7000 years, and that Eastern and Southern Niger-Congo speaking groups share ancestry with Central West Africans as a result of recent population expansions. In fact, most sub-Saharan populations share ancestry with groups from outside of their current geographic region as a result of gene-flow within the last 4000 years. Our in-depth analysis provides insight into haplotype sharing across different ethno-linguistic groups and the recent movement of alleles into new environments, both of which are relevant to studies of genetic epidemiology.

UR - https://www.scopus.com/pages/publications/84975491862

U2 - 10.7554/eLife.15266.001

DO - 10.7554/eLife.15266.001

M3 - Article

C2 - 27324836

AN - SCOPUS:84975491862

SN - 2050-084X

VL - 5

JO - eLife

JF - eLife

IS - JUN2016

M1 - e15266

ER -

Admixture into and within sub-Saharan Africa

Abstract

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