TY - JOUR
T1 - Admixture into and within sub-Saharan Africa
AU - Malaria Genomic Epidemiology Network
AU - Busby, George B.J.
AU - Band, Gavin
AU - Le, Quang Si
AU - Jallow, Muminatou
AU - Bougama, Edith
AU - Mangano, Valentina D.
AU - Amenga-Etego, Lucas N.
AU - Enimil, Anthony
AU - Apinjoh, Tobias
AU - Ndila, Carolyne M.
AU - Manjurano, Alphaxard
AU - Nyirongo, Vysaul
AU - Doumba, Ogobara
AU - Rockett, Kirk A.
AU - Kwiatkowski, Dominic P.
AU - Spencer, Chris C.A.
AU - Vanderwal, Aaron
AU - Elzein, Abier
AU - Nyika, Aceme
AU - Mendy, Alieu
AU - Miles, Alistair
AU - Diss, Andrea
AU - Kerasidou, Angeliki
AU - Green, Angie
AU - Jeffreys, Anna E.
AU - MacInnis, Bronwyn
AU - Hughes, Catherine
AU - Moyes, Catherine
AU - Hubbart, Christina
AU - Malangone, Cinzia
AU - Potter, Claire
AU - Mead, Daniel
AU - Barnwell, David
AU - Jyothi, Dushyanth
AU - Drury, Eleanor
AU - Somaskantharajah, Elilan
AU - Hilton, Eliza
AU - Leffler, Ellen
AU - Maslen, Gareth
AU - Busby, George
AU - Clarke, Geraldine M.
AU - Ragoussis, Ioannis
AU - Garcia, Jacob Almagro
AU - Rogers, Jane
AU - deVries, Jantina
AU - Shelton, Jennifer
AU - Ragoussis, Jiannis
AU - Stalker, Jim
AU - Rodford, Joanne
AU - Ghansah, Anita
N1 - Publisher Copyright:
© Busby et al.
PY - 2016/6/21
Y1 - 2016/6/21
N2 - Similarity between two individuals in the combination of genetic markers along their chromosomes indicates shared ancestry and can be used to identify historical connections between different population groups due to admixture. We use a genome-wide, haplotype-based, analysis to characterise the structure of genetic diversity and gene-flow in a collection of 48 sub-Saharan African groups. We show that coastal populations experienced an influx of Eurasian haplotypes over the last 7000 years, and that Eastern and Southern Niger-Congo speaking groups share ancestry with Central West Africans as a result of recent population expansions. In fact, most sub-Saharan populations share ancestry with groups from outside of their current geographic region as a result of gene-flow within the last 4000 years. Our in-depth analysis provides insight into haplotype sharing across different ethno-linguistic groups and the recent movement of alleles into new environments, both of which are relevant to studies of genetic epidemiology.
AB - Similarity between two individuals in the combination of genetic markers along their chromosomes indicates shared ancestry and can be used to identify historical connections between different population groups due to admixture. We use a genome-wide, haplotype-based, analysis to characterise the structure of genetic diversity and gene-flow in a collection of 48 sub-Saharan African groups. We show that coastal populations experienced an influx of Eurasian haplotypes over the last 7000 years, and that Eastern and Southern Niger-Congo speaking groups share ancestry with Central West Africans as a result of recent population expansions. In fact, most sub-Saharan populations share ancestry with groups from outside of their current geographic region as a result of gene-flow within the last 4000 years. Our in-depth analysis provides insight into haplotype sharing across different ethno-linguistic groups and the recent movement of alleles into new environments, both of which are relevant to studies of genetic epidemiology.
UR - http://www.scopus.com/inward/record.url?scp=84975491862&partnerID=8YFLogxK
U2 - 10.7554/eLife.15266.001
DO - 10.7554/eLife.15266.001
M3 - Article
C2 - 27324836
AN - SCOPUS:84975491862
SN - 2050-084X
VL - 5
JO - eLife
JF - eLife
IS - JUN2016
M1 - e15266
ER -